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Engineering pan-HIV-1 neutralization potency through multispecific antibody avidity.
Rujas E, Cui H, Burnie J, Aschner CB, Zhao T, Insausti S, Muthuraman K, Semesi A, Ophel J, Nieva JL, Seaman MS, Guzzo C, Treanor B, Julien JP. Rujas E, et al. Among authors: cui h. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2112887119. doi: 10.1073/pnas.2112887119. Proc Natl Acad Sci U S A. 2022. PMID: 35064083 Free PMC article.
Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers.
Rujas E, Kucharska I, Tan YZ, Benlekbir S, Cui H, Zhao T, Wasney GA, Budylowski P, Guvenc F, Newton JC, Sicard T, Semesi A, Muthuraman K, Nouanesengsy A, Aschner CB, Prieto K, Bueler SA, Youssef S, Liao-Chan S, Glanville J, Christie-Holmes N, Mubareka S, Gray-Owen SD, Rubinstein JL, Treanor B, Julien JP. Rujas E, et al. Among authors: cui h. Nat Commun. 2021 Jun 16;12(1):3661. doi: 10.1038/s41467-021-23825-2. Nat Commun. 2021. PMID: 34135340 Free PMC article.
Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile.
Rujas E, Leaman DP, Insausti S, Carravilla P, García-Porras M, Largo E, Morillo I, Sánchez-Eugenia R, Zhang L, Cui H, Iloro I, Elortza F, Julien JP, Eggeling C, Zwick MB, Caaveiro JMM, Nieva JL. Rujas E, et al. Among authors: cui h. iScience. 2021 Aug 17;24(9):102987. doi: 10.1016/j.isci.2021.102987. eCollection 2021 Sep 24. iScience. 2021. PMID: 34505005 Free PMC article.
Molecular basis of human CD22 function and therapeutic targeting.
Ereño-Orbea J, Sicard T, Cui H, Mazhab-Jafari MT, Benlekbir S, Guarné A, Rubinstein JL, Julien JP. Ereño-Orbea J, et al. Among authors: cui h. Nat Commun. 2017 Oct 2;8(1):764. doi: 10.1038/s41467-017-00836-6. Nat Commun. 2017. PMID: 28970495 Free PMC article.
7,729 results