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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.
Stormo AED, Shavarebi F, FitzGibbon M, Earley EM, Ahrendt H, Lum LS, Verschueren E, Swaney DL, Skibinski G, Ravisankar A, van Haren J, Davis EJ, Johnson JR, Von Dollen J, Balen C, Porath J, Crosio C, Mirescu C, Iaccarino C, Dauer WT, Nichols RJ, Wittmann T, Cox TC, Finkbeiner S, Krogan NJ, Oakes SA, Hiniker A. Stormo AED, et al. Among authors: crosio c. J Cell Biol. 2022 Apr 4;221(4):e202010065. doi: 10.1083/jcb.202010065. Epub 2022 Mar 10. J Cell Biol. 2022. PMID: 35266954 Free PMC article.
Apoptotic mechanisms in mutant LRRK2-mediated cell death.
Iaccarino C, Crosio C, Vitale C, Sanna G, Carrì MT, Barone P. Iaccarino C, et al. Among authors: crosio c. Hum Mol Genet. 2007 Jun 1;16(11):1319-26. doi: 10.1093/hmg/ddm080. Epub 2007 Apr 4. Hum Mol Genet. 2007. PMID: 17409193 Free article.
LRRK2 and vesicle trafficking.
Sanna G, Del Giudice MG, Crosio C, Iaccarino C. Sanna G, et al. Among authors: crosio c. Biochem Soc Trans. 2012 Oct;40(5):1117-22. doi: 10.1042/BST20120117. Biochem Soc Trans. 2012. PMID: 22988875 Review.
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
Reyniers L, Del Giudice MG, Civiero L, Belluzzi E, Lobbestael E, Beilina A, Arrigoni G, Derua R, Waelkens E, Li Y, Crosio C, Iaccarino C, Cookson MR, Baekelandt V, Greggio E, Taymans JM. Reyniers L, et al. Among authors: crosio c. J Neurochem. 2014 Oct;131(2):239-50. doi: 10.1111/jnc.12798. Epub 2014 Jul 14. J Neurochem. 2014. PMID: 24947832 Free PMC article.
Role of LRRK2 in the regulation of dopamine receptor trafficking.
Rassu M, Del Giudice MG, Sanna S, Taymans JM, Morari M, Brugnoli A, Frassineti M, Masala A, Esposito S, Galioto M, Valle C, Carri MT, Biosa A, Greggio E, Crosio C, Iaccarino C. Rassu M, et al. Among authors: crosio c. PLoS One. 2017 Jun 5;12(6):e0179082. doi: 10.1371/journal.pone.0179082. eCollection 2017. PLoS One. 2017. PMID: 28582422 Free PMC article.
Levetiracetam treatment ameliorates LRRK2 pathological mutant phenotype.
Rassu M, Biosa A, Galioto M, Fais M, Sini P, Greggio E, Piccoli G, Crosio C, Iaccarino C. Rassu M, et al. Among authors: crosio c. J Cell Mol Med. 2019 Dec;23(12):8505-8510. doi: 10.1111/jcmm.14674. Epub 2019 Sep 27. J Cell Mol Med. 2019. PMID: 31560168 Free PMC article.
LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8.
Fais M, Sanna G, Galioto M, Nguyen TTD, Trần MUT, Sini P, Carta F, Turrini F, Xiong Y, Dawson TM, Dawson VL, Crosio C, Iaccarino C. Fais M, et al. Among authors: crosio c. Cells. 2021 Jan 20;10(2):203. doi: 10.3390/cells10020203. Cells. 2021. PMID: 33498474 Free PMC article.
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