Cremades N - Search Results

1

All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species.

Franco A, Gracia P, Colom A, Camino JD, Fernández-Higuero JÁ, Orozco N, Dulebo A, Saiz L, Cremades N, Vilar JMG, Prado A, Muga A. Franco A, et al. Among authors: cremades n. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2105548118. doi: 10.1073/pnas.2105548118. Proc Natl Acad Sci U S A. 2021. PMID: 34462355 Free PMC article.

2

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

Chen SW, Drakulic S, Deas E, Ouberai M, Aprile FA, Arranz R, Ness S, Roodveldt C, Guilliams T, De-Genst EJ, Klenerman D, Wood NW, Knowles TP, Alfonso C, Rivas G, Abramov AY, Valpuesta JM, Dobson CM, Cremades N. Chen SW, et al. Among authors: cremades n. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1994-2003. doi: 10.1073/pnas.1421204112. Epub 2015 Apr 8. Proc Natl Acad Sci U S A. 2015. PMID: 25855634 Free PMC article.

3

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing.

Pedersen JT, Chen SW, Borg CB, Ness S, Bahl JM, Heegaard NH, Dobson CM, Hemmingsen L, Cremades N, Teilum K. Pedersen JT, et al. Among authors: cremades n. J Am Chem Soc. 2016 Mar 30;138(12):3966-9. doi: 10.1021/jacs.5b13577. Epub 2016 Mar 21. J Am Chem Soc. 2016. PMID: 26967463 Free PMC article.

4

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.

Perni M, Galvagnion C, Maltsev A, Meisl G, Müller MB, Challa PK, Kirkegaard JB, Flagmeier P, Cohen SI, Cascella R, Chen SW, Limbocker R, Sormanni P, Heller GT, Aprile FA, Cremades N, Cecchi C, Chiti F, Nollen EA, Knowles TP, Vendruscolo M, Bax A, Zasloff M, Dobson CM. Perni M, et al. Among authors: cremades n. Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E1009-E1017. doi: 10.1073/pnas.1610586114. Epub 2017 Jan 17. Proc Natl Acad Sci U S A. 2017. PMID: 28096355 Free PMC article.

5

Structural Characteristics of α-Synuclein Oligomers.

Cremades N, Chen SW, Dobson CM. Cremades N, et al. Int Rev Cell Mol Biol. 2017;329:79-143. doi: 10.1016/bs.ircmb.2016.08.010. Epub 2016 Oct 31. Int Rev Cell Mol Biol. 2017. PMID: 28109332 Review.

6

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.

Aprile FA, Arosio P, Fusco G, Chen SW, Kumita JR, Dhulesia A, Tortora P, Knowles TP, Vendruscolo M, Dobson CM, Cremades N. Aprile FA, et al. Among authors: cremades n. Biochemistry. 2017 Mar 7;56(9):1177-1180. doi: 10.1021/acs.biochem.6b01178. Epub 2017 Feb 23. Biochemistry. 2017. PMID: 28230968

7

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.

Fusco G, Chen SW, Williamson PTF, Cascella R, Perni M, Jarvis JA, Cecchi C, Vendruscolo M, Chiti F, Cremades N, Ying L, Dobson CM, De Simone A. Fusco G, et al. Among authors: cremades n. Science. 2017 Dec 15;358(6369):1440-1443. doi: 10.1126/science.aan6160. Science. 2017. PMID: 29242346 Free article.

8

Preparation of α-Synuclein Amyloid Assemblies for Toxicity Experiments.

Chen SW, Cremades N. Chen SW, et al. Among authors: cremades n. Methods Mol Biol. 2018;1779:45-60. doi: 10.1007/978-1-4939-7816-8_4. Methods Mol Biol. 2018. PMID: 29886526

9

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM. Perni M, et al. Among authors: cremades n. ACS Chem Biol. 2018 Aug 17;13(8):2308-2319. doi: 10.1021/acschembio.8b00466. Epub 2018 Jun 28. ACS Chem Biol. 2018. PMID: 29953201

10

Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.

Froula JM, Castellana-Cruz M, Anabtawi NM, Camino JD, Chen SW, Thrasher DR, Freire J, Yazdi AA, Fleming S, Dobson CM, Kumita JR, Cremades N, Volpicelli-Daley LA. Froula JM, et al. Among authors: cremades n. J Biol Chem. 2019 Jul 5;294(27):10392-10406. doi: 10.1074/jbc.RA119.007743. Epub 2019 May 29. J Biol Chem. 2019. PMID: 31142553 Free PMC article.

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