Court WJ - Search Results

1

The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium.

Wilsher NE, Court WJ, Ruddle R, Newbatt YM, Aherne W, Sheldrake PW, Jones NP, Katan M, Eccles SA, Raynaud FI. Wilsher NE, et al. Among authors: court wj. Drug Metab Dispos. 2007 Jul;35(7):1017-22. doi: 10.1124/dmd.106.014498. Epub 2007 Apr 2. Drug Metab Dispos. 2007. PMID: 17403917

2

The identification of novel PLC-gamma inhibitors using virtual high throughput screening.

Reynisson J, Court W, O'Neill C, Day J, Patterson L, McDonald E, Workman P, Katan M, Eccles SA. Reynisson J, et al. Bioorg Med Chem. 2009 Apr 15;17(8):3169-76. doi: 10.1016/j.bmc.2009.02.049. Epub 2009 Mar 3. Bioorg Med Chem. 2009. PMID: 19303309

3

Cell migration/invasion assays and their application in cancer drug discovery.

Eccles SA, Box C, Court W. Eccles SA, et al. Biotechnol Annu Rev. 2005;11:391-421. doi: 10.1016/S1387-2656(05)11013-8. Biotechnol Annu Rev. 2005. PMID: 16216785 Review.

4

In vitro assays for endothelial cell functions related to angiogenesis: proliferation, motility, tubular differentiation, and proteolysis.

Eccles SA, Court W, Patterson L, Sanderson S. Eccles SA, et al. Methods Mol Biol. 2009;467:159-81. doi: 10.1007/978-1-59745-241-0_9. Methods Mol Biol. 2009. PMID: 19301670

5

In Vitro Assays for Endothelial Cell Functions Required for Angiogenesis: Proliferation, Motility, Tubular Differentiation, and Matrix Proteolysis.

Eccles SA, Court W, Patterson L. Eccles SA, et al. Methods Mol Biol. 2016;1430:121-47. doi: 10.1007/978-1-4939-3628-1_8. Methods Mol Biol. 2016. PMID: 27172950

6

Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.

Mallinger A, Crumpler S, Pichowicz M, Waalboer D, Stubbs M, Adeniji-Popoola O, Wood B, Smith E, Thai C, Henley AT, Georgi K, Court W, Hobbs S, Box G, Ortiz-Ruiz MJ, Valenti M, De Haven Brandon A, TePoele R, Leuthner B, Workman P, Aherne W, Poeschke O, Dale T, Wienke D, Esdar C, Rohdich F, Raynaud F, Clarke PA, Eccles SA, Stieber F, Schiemann K, Blagg J. Mallinger A, et al. J Med Chem. 2015 Feb 26;58(4):1717-35. doi: 10.1021/jm501436m. Epub 2015 Feb 13. J Med Chem. 2015. PMID: 25680029 Free PMC article.

7

ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycin.

Smith V, Hobbs S, Court W, Eccles S, Workman P, Kelland LR. Smith V, et al. Anticancer Res. 2002 Jul-Aug;22(4):1993-9. Anticancer Res. 2002. PMID: 12174876

8

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation.

Vinci M, Gowan S, Boxall F, Patterson L, Zimmermann M, Court W, Lomas C, Mendiola M, Hardisson D, Eccles SA. Vinci M, et al. BMC Biol. 2012 Mar 22;10:29. doi: 10.1186/1741-7007-10-29. BMC Biol. 2012. PMID: 22439642 Free PMC article.

9

Differential modulation of proliferation, matrix metalloproteinase expression and invasion of human head and neck squamous carcinoma cells by c-erbB ligands.

O-charoenrat P, Rhys-Evans P, Court WJ, Box GM, Eccles SA. O-charoenrat P, et al. Among authors: court wj. Clin Exp Metastasis. 1999;17(7):631-9. doi: 10.1023/a:1006751016860. Clin Exp Metastasis. 1999. PMID: 10845563

10

Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck.

Luangdilok S, Box C, Patterson L, Court W, Harrington K, Pitkin L, Rhŷs-Evans P, O-charoenrat P, Eccles S. Luangdilok S, et al. Cancer Res. 2007 Aug 15;67(16):7907-16. doi: 10.1158/0008-5472.CAN-07-0331. Cancer Res. 2007. PMID: 17699797

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