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GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions.
Brun S, Bestion E, Raymond E, Bassissi F, Jilkova ZM, Mezouar S, Rachid M, Novello M, Tracz J, Hamaï A, Lalmanach G, Vanderlynden L, Legouffe R, Stauber J, Schubert T, Plach MG, Courcambeck J, Drouot C, Jacquemot G, Serdjebi C, Roth G, Baudoin JP, Ansaldi C, Decaens T, Halfon P. Brun S, et al. Among authors: courcambeck j. Autophagy. 2022 Mar;18(3):678-694. doi: 10.1080/15548627.2021.1988357. Epub 2021 Nov 5. Autophagy. 2022. PMID: 34740311 Free PMC article.
GNS561, a New Autophagy Inhibitor Active against Cancer Stem Cells in Hepatocellular Carcinoma and Hepatic Metastasis from Colorectal Cancer.
Brun S, Pascussi JM, Gifu EP, Bestion E, Macek-Jilkova Z, Wang G, Bassissi F, Mezouar S, Courcambeck J, Merle P, Decaens T, Pannequin J, Halfon P, Caron de Fromentel C. Brun S, et al. Among authors: courcambeck j. J Cancer. 2021 Jul 13;12(18):5432-5438. doi: 10.7150/jca.58533. eCollection 2021. J Cancer. 2021. PMID: 34405006 Free PMC article.
GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition.
Bestion E, Jilkova ZM, Mège JL, Novello M, Kurma K, Pour STA, Lalmanach G, Vanderlynden L, Fizanne L, Bassissi F, Rachid M, Tracz J, Boursier J, Courcambeck J, Serdjebi C, Ansaldi C, Decaens T, Halfon P, Brun S. Bestion E, et al. Among authors: courcambeck j. Ther Adv Chronic Dis. 2020 Jul 16;11:2040622320942042. doi: 10.1177/2040622320942042. eCollection 2020. Ther Adv Chronic Dis. 2020. PMID: 32728410 Free PMC article.
A loss of viral replicative capacity correlates with altered DNA polymerization kinetics by the human immunodeficiency virus reverse transcriptase bearing the K65R and L74V dideoxynucleoside resistance substitutions.
Deval J, Navarro JM, Selmi B, Courcambeck J, Boretto J, Halfon P, Garrido-Urbani S, Sire J, Canard B. Deval J, et al. Among authors: courcambeck j. J Biol Chem. 2004 Jun 11;279(24):25489-96. doi: 10.1074/jbc.M313534200. Epub 2004 Mar 23. J Biol Chem. 2004. PMID: 15044478 Free article.
17 results