Coukos JS - Search Results

1

Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains.

Speltz TE, Qiao Z, Swenson CS, Shangguan X, Coukos JS, Lee CW, Thomas DM, Santana J, Fanning SW, Greene GL, Moellering RE. Speltz TE, et al. Among authors: coukos js. Nat Biotechnol. 2023 Apr;41(4):541-551. doi: 10.1038/s41587-022-01504-x. Epub 2022 Oct 27. Nat Biotechnol. 2023. PMID: 36302987 Free PMC article.

2

Profiling Reactive Metabolites via Chemical Trapping and Targeted Mass Spectrometry.

Chang JW, Lee G, Coukos JS, Moellering RE. Chang JW, et al. Among authors: coukos js. Anal Chem. 2016 Jul 5;88(13):6658-61. doi: 10.1021/acs.analchem.6b02009. Epub 2016 Jun 23. Anal Chem. 2016. PMID: 27314642 Free PMC article.

3

A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.

Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE. Bollong MJ, et al. Among authors: coukos js. Nature. 2018 Oct;562(7728):600-604. doi: 10.1038/s41586-018-0622-0. Epub 2018 Oct 15. Nature. 2018. PMID: 30323285 Free PMC article.

4

Versatile Peptide Macrocyclization with Diels-Alder Cycloadditions.

Montgomery JE, Donnelly JA, Fanning SW, Speltz TE, Shangguan X, Coukos JS, Greene GL, Moellering RE. Montgomery JE, et al. Among authors: coukos js. J Am Chem Soc. 2019 Oct 16;141(41):16374-16381. doi: 10.1021/jacs.9b07578. Epub 2019 Sep 26. J Am Chem Soc. 2019. PMID: 31523967 Free PMC article.

5

Interaction profiling methods to map protein and pathway targets of bioactive ligands.

Huang JX, Coukos JS, Moellering RE. Huang JX, et al. Among authors: coukos js. Curr Opin Chem Biol. 2020 Feb;54:76-84. doi: 10.1016/j.cbpa.2020.02.001. Epub 2020 Mar 5. Curr Opin Chem Biol. 2020. PMID: 32146330 Free PMC article. Review.

6

Corrigendum to "Interaction profiling methods to map protein and pathway targets of bioactive ligands", [Curr Opin Chem Biol 54 (February 2020) 76-84].

Huang JX, Coukos JS, Moellering RE. Huang JX, et al. Among authors: coukos js. Curr Opin Chem Biol. 2021 Aug;63:230. doi: 10.1016/j.cbpa.2020.10.005. Epub 2020 Nov 19. Curr Opin Chem Biol. 2021. PMID: 33223432 No abstract available.

7

Methylglyoxal Forms Diverse Mercaptomethylimidazole Crosslinks with Thiol and Guanidine Pairs in Endogenous Metabolites and Proteins.

Coukos JS, Moellering RE. Coukos JS, et al. ACS Chem Biol. 2021 Nov 19;16(11):2453-2461. doi: 10.1021/acschembio.1c00553. Epub 2021 Sep 28. ACS Chem Biol. 2021. PMID: 34581579 Free PMC article.

8

Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function.

Coukos JS, Lee CW, Pillai KS, Liu KJ, Moellering RE. Coukos JS, et al. ACS Chem Biol. 2023 Jan 20;18(1):91-101. doi: 10.1021/acschembio.2c00727. Epub 2022 Dec 23. ACS Chem Biol. 2023. PMID: 36562291 Free PMC article.

9

LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.

Stein BD, Ferrarone JR, Gardner EE, Chang JW, Wu D, Hollstein PE, Liang RJ, Yuan M, Chen Q, Coukos JS, Sindelar M, Ngo B, Gross SS, Shaw RJ, Zhang C, Asara JM, Moellering RE, Varmus H, Cantley LC. Stein BD, et al. Among authors: coukos js. Cancer Discov. 2023 Apr 3;13(4):1002-1025. doi: 10.1158/2159-8290.CD-22-0805. Cancer Discov. 2023. PMID: 36715544 Free PMC article.

10

PARK7 Catalyzes Stereospecific Detoxification of Methylglyoxal Consistent with Glyoxalase and Not Deglycase Function.

Coukos JS, Lee CW, Pillai KS, Shah H, Moellering RE. Coukos JS, et al. Biochemistry. 2023 Nov 7;62(21):3126-3133. doi: 10.1021/acs.biochem.3c00325. Epub 2023 Oct 26. Biochemistry. 2023. PMID: 37884446 Free PMC article.

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