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Design, synthesis and cytotoxicity of the antitumor agent 1-azabicycles for chemoresistant glioblastoma cells.
Oliveira M, de Santana LLB, Serafim JC, Santos AO, Quintino MP, Correia JTM, Damasceno F, Sabino JR, Pires TRC, Coelho PLC, de Faria Lopes GP, Ulrich H, Costa SL, Cunha S. Oliveira M, et al. Among authors: costa sl. Invest New Drugs. 2020 Oct;38(5):1257-1271. doi: 10.1007/s10637-019-00877-2. Epub 2019 Dec 14. Invest New Drugs. 2020. PMID: 31838735
Genotoxicity and morphological changes induced by the alkaloid monocrotaline, extracted from Crotalaria retusa, in a model of glial cells.
Silva-Neto JP, Barreto RA, Pitanga BP, Souza CS, Silva VD, Silva AR, Velozo ES, Cunha SD, Batatinha MJ, Tardy M, Ribeiro CS, Costa MF, El-Bachá RS, Costa SL. Silva-Neto JP, et al. Among authors: costa mf, costa sl. Toxicon. 2010 Jan;55(1):105-17. doi: 10.1016/j.toxicon.2009.07.007. Epub 2009 Jul 15. Toxicon. 2010. PMID: 19615397
Antiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cells.
Santos BL, Silva AR, Pitanga BP, Sousa CS, Grangeiro MS, Fragomeni BO, Coelho PL, Oliveira MN, Menezes-Filho NJ, Costa MF, El-Bachá RS, Velozo ES, Sampaio GP, Freire SM, Tardy M, Costa SL. Santos BL, et al. Among authors: costa mf, costa sl. Food Chem. 2011 Jul 15;127(2):404-11. doi: 10.1016/j.foodchem.2010.12.131. Epub 2011 Jan 8. Food Chem. 2011. PMID: 23140679
Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression.
Santos BL, Oliveira MN, Coelho PL, Pitanga BP, da Silva AB, Adelita T, Silva VD, Costa Mde F, El-Bachá RS, Tardy M, Chneiweiss H, Junier MP, Moura-Neto V, Costa SL. Santos BL, et al. Among authors: costa sl, costa mde f. Chem Biol Interact. 2015 Dec 5;242:123-38. doi: 10.1016/j.cbi.2015.07.014. Epub 2015 Sep 25. Chem Biol Interact. 2015. PMID: 26408079
The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
Assad Kahn S, Costa SL, Gholamin S, Nitta RT, Dubois LG, Fève M, Zeniou M, Coelho PL, El-Habr E, Cadusseau J, Varlet P, Mitra SS, Devaux B, Kilhoffer MC, Cheshier SH, Moura-Neto V, Haiech J, Junier MP, Chneiweiss H. Assad Kahn S, et al. Among authors: costa sl. EMBO Mol Med. 2016 May 2;8(5):511-26. doi: 10.15252/emmm.201505421. Print 2016 May. EMBO Mol Med. 2016. PMID: 27138566 Free PMC article.
Specific Cytostatic and Cytotoxic Effect of Dihydrochelerythrine in Glioblastoma Cells: Role of NF-κB/β-catenin and STAT3/IL-6 Pathways.
Silva TCC, de Faria Lopes GP, de J Menezes-Filho N, de Oliveira DM, Pereira E, Pitanga BPS, Dos Santos Costa R, da Silva Velozo E, Freire SM, Clarêncio J, Borges HL, Rehen SK, Moura-Neto V, Costa SL. Silva TCC, et al. Among authors: costa sl. Anticancer Agents Med Chem. 2018;18(10):1386-1393. doi: 10.2174/1871520618666180412122101. Anticancer Agents Med Chem. 2018. PMID: 29651966
The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity.
da Silva AB, Cerqueira Coelho PL, das Neves Oliveira M, Oliveira JL, Oliveira Amparo JA, da Silva KC, Soares JRP, Pitanga BPS, Dos Santos Souza C, de Faria Lopes GP, da Silva VDA, de Fátima Dias Costa M, Junier MP, Chneiweiss H, Moura-Neto V, Costa SL. da Silva AB, et al. Among authors: costa sl. Brain Behav Immun. 2020 Mar;85:170-185. doi: 10.1016/j.bbi.2019.05.003. Epub 2019 May 3. Brain Behav Immun. 2020. PMID: 31059805
Reverted effect of mesenchymal stem cells in glioblastoma treated with agathisflavone and its selective antitumoral effect on cell viability, migration, and differentiation via STAT3.
Nascimento RP, Dos Santos BL, da Silva KC, Amaral da Silva VD, de Fátima Costa M, David JM, David JP, Moura-Neto V, Oliveira MDN, Ulrich H, de Faria Lopes GP, Costa SL. Nascimento RP, et al. Among authors: costa sl. J Cell Physiol. 2021 Jul;236(7):5022-5035. doi: 10.1002/jcp.30209. Epub 2020 Dec 23. J Cell Physiol. 2021. PMID: 33368262
127 results