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Halogen substitution of DNA protects from poisoning of topoisomerase II that results in DNA double-strand breaks.
Cantero G, Mateos S, Pastor N, Cortés F. Cantero G, et al. Among authors: cortes f. DNA Repair (Amst). 2006 Jun 10;5(6):667-74. doi: 10.1016/j.dnarep.2005.11.008. Epub 2006 Jan 10. DNA Repair (Amst). 2006. PMID: 16406738
DNA topoisomerase II (topo II), a fundamental nuclear enzyme, cleaves the double-stranded DNA molecule at preferred sequences within its recognition/binding sites. We have recently reported [F. Cortes, N. Pastor, S. Mateos, I. Dominguez, The nature of DNA plays a ro …
DNA topoisomerase II (topo II), a fundamental nuclear enzyme, cleaves the double-stranded DNA molecule at preferred sequences within its rec …
Protection of halogenated DNA from strand breakage and sister-chromatid exchange induced by the topoisomerase I inhibitor camptothecin.
Orta ML, Mateos S, Cantero G, Wolff LJ, Cortés F. Orta ML, et al. Among authors: cortes f. Mutat Res. 2008 Jan 1;637(1-2):40-8. doi: 10.1016/j.mrfmmm.2007.06.012. Epub 2007 Jul 10. Mutat Res. 2008. PMID: 17706727
We have recently reported that when cells incorporate halogenated nucleosides analogues of thymidine into DNA, it interferes with normal chromosome segregation, as shown by an extraordinarily high yield of endoreduplication, and results in a protection against DNA breakage induce …
We have recently reported that when cells incorporate halogenated nucleosides analogues of thymidine into DNA, it interferes with normal chr …
315 results