Halogen substitution of DNA protects from poisoning of topoisomerase II that results in DNA double-strand breaks.
Cantero G, Mateos S, Pastor N, Cortés F.
Cantero G, et al. Among authors: cortes f.
DNA Repair (Amst). 2006 Jun 10;5(6):667-74. doi: 10.1016/j.dnarep.2005.11.008. Epub 2006 Jan 10.
DNA Repair (Amst). 2006.
PMID: 16406738
DNA topoisomerase II (topo II), a fundamental nuclear enzyme, cleaves the double-stranded DNA molecule at preferred sequences within its recognition/binding sites. We have recently reported [F. Cortes, N. Pastor, S. Mateos, I. Dominguez, The nature of DNA plays a ro …
DNA topoisomerase II (topo II), a fundamental nuclear enzyme, cleaves the double-stranded DNA molecule at preferred sequences within its rec …