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Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing.
Knipping F, Newby GA, Eide CR, McElroy AN, Nielsen SC, Smith K, Fang Y, Cornu TI, Costa C, Gutierrez-Guerrero A, Bingea SP, Feser CJ, Steinbeck B, Hippen KL, Blazar BR, McCaffrey A, Mussolino C, Verhoeyen E, Tolar J, Liu DR, Osborn MJ. Knipping F, et al. Among authors: cornu ti. Mol Ther. 2022 Jan 5;30(1):130-144. doi: 10.1016/j.ymthe.2021.10.026. Epub 2021 Nov 2. Mol Ther. 2022. PMID: 34737067 Free PMC article.
Editing CCR5: a novel approach to HIV gene therapy.
Cornu TI, Mussolino C, Bloom K, Cathomen T. Cornu TI, et al. Adv Exp Med Biol. 2015;848:117-30. doi: 10.1007/978-1-4939-2432-5_6. Adv Exp Med Biol. 2015. PMID: 25757618 Review.
Correction of IVS I-110(G>A) β-thalassemia by CRISPR/Cas-and TALEN-mediated disruption of aberrant regulatory elements in human hematopoietic stem and progenitor cells.
Patsali P, Turchiano G, Papasavva P, Romito M, Loucari CC, Stephanou C, Christou S, Sitarou M, Mussolino C, Cornu TI, Antoniou MN, Lederer CW, Cathomen T, Kleanthous M. Patsali P, et al. Among authors: cornu ti. Haematologica. 2019 Nov;104(11):e497-e501. doi: 10.3324/haematol.2018.215178. Epub 2019 Apr 19. Haematologica. 2019. PMID: 31004018 Free PMC article. No abstract available.
Preclinical Evaluation of a Novel TALEN Targeting CCR5 Confirms Efficacy and Safety in Conferring Resistance to HIV-1 Infection.
Romito M, Juillerat A, Kok YL, Hildenbeutel M, Rhiel M, Andrieux G, Geiger J, Rudolph C, Mussolino C, Duclert A, Metzner KJ, Duchateau P, Cathomen T, Cornu TI. Romito M, et al. Among authors: cornu ti. Biotechnol J. 2021 Jan;16(1):e2000023. doi: 10.1002/biot.202000023. Epub 2020 Nov 16. Biotechnol J. 2021. PMID: 33103367 Free article.
HIV Gene Therapy: An Update.
Cornu TI, Mussolino C, Müller MC, Wehr C, Kern WV, Cathomen T. Cornu TI, et al. Hum Gene Ther. 2021 Jan;32(1-2):52-65. doi: 10.1089/hum.2020.159. Hum Gene Ther. 2021. PMID: 33349126 Review.
Automated generation of gene-edited CAR T cells at clinical scale.
Alzubi J, Lock D, Rhiel M, Schmitz S, Wild S, Mussolino C, Hildenbeutel M, Brandes C, Rositzka J, Lennartz S, Haas SA, Chmielewski KO, Schaser T, Kaiser A, Cathomen T, Cornu TI. Alzubi J, et al. Among authors: cornu ti. Mol Ther Methods Clin Dev. 2020 Dec 25;20:379-388. doi: 10.1016/j.omtm.2020.12.008. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2020. PMID: 33575430 Free PMC article.
37 results