Copeland RA - Search Results

1

Steric Perturbation of the Grob-like Final Step of Ethylene-Forming Enzyme Enables 3-Hydroxypropionate and Propylene Production.

Burke EJ, Copeland RA, Dixit Y, Krebs C, Bollinger JM Jr. Burke EJ, et al. Among authors: copeland ra. J Am Chem Soc. 2024 Jan 24;146(3):1977-1983. doi: 10.1021/jacs.3c09733. Epub 2024 Jan 16. J Am Chem Soc. 2024. PMID: 38226594

2

Development of assays to support identification and characterization of modulators of DExH-box helicase DHX9.

Gotur D, Case A, Liu J, Sickmier EA, Holt N, Knockenhauer KE, Yao S, Lee YT, Copeland RA, Buker SM, Boriack-Sjodin PA. Gotur D, et al. Among authors: copeland ra. SLAS Discov. 2023 Dec;28(8):376-384. doi: 10.1016/j.slasd.2023.08.006. Epub 2023 Aug 23. SLAS Discov. 2023. PMID: 37625785 Free article.

3

The importance of binding kinetics and drug-target residence time in pharmacology.

Knockenhauer KE, Copeland RA. Knockenhauer KE, et al. Among authors: copeland ra. Br J Pharmacol. 2023 May 9. doi: 10.1111/bph.16104. Online ahead of print. Br J Pharmacol. 2023. PMID: 37160660 Free article. Review.

4

Corrigendum to "Impact of enzyme concentration and residence time on apparent activity recovery in jump dilution analysis" [Anal. Biochem. 416 (2011) 206-210].

Copeland RA, Basavapathruni A, Moyer M, Porter Scott M. Copeland RA, et al. Anal Biochem. 2022 May 15;645:114637. doi: 10.1016/j.ab.2022.114637. Epub 2022 Mar 3. Anal Biochem. 2022. PMID: 35249722 No abstract available.

5

Hybrid radical-polar pathway for excision of ethylene from 2-oxoglutarate by an iron oxygenase.

Copeland RA, Zhou S, Schaperdoth I, Shoda TKC, Bollinger JM Jr, Krebs C. Copeland RA, et al. Science. 2021 Sep 24;373(6562):1489-1493. doi: 10.1126/science.abj4290. Epub 2021 Aug 13. Science. 2021. PMID: 34385355

6

Chance Favors the Perplexed Mind: The Critical Role of Mechanistic Biochemistry in Drug Discovery.

Copeland RA. Copeland RA. Biochemistry. 2021 Jul 27;60(29):2275-2284. doi: 10.1021/acs.biochem.1c00345. Epub 2021 Jul 14. Biochemistry. 2021. PMID: 34259514

7

Evolution of the drug-target residence time model.

Copeland RA. Copeland RA. Expert Opin Drug Discov. 2021 Dec;16(12):1441-1451. doi: 10.1080/17460441.2021.1948997. Epub 2021 Jul 1. Expert Opin Drug Discov. 2021. PMID: 34210223

8

An Iron(IV)-Oxo Intermediate Initiating l-Arginine Oxidation but Not Ethylene Production by the 2-Oxoglutarate-Dependent Oxygenase, Ethylene-Forming Enzyme.

Copeland RA, Davis KM, Shoda TKC, Blaesi EJ, Boal AK, Krebs C, Bollinger JM Jr. Copeland RA, et al. J Am Chem Soc. 2021 Feb 10;143(5):2293-2303. doi: 10.1021/jacs.0c10923. Epub 2021 Feb 1. J Am Chem Soc. 2021. PMID: 33522811 Free PMC article.

9

Special Issue on Epigenetics: Targeting Chromatin- and RNA- Modifications.

Copeland RA, Huryn DM. Copeland RA, et al. ACS Med Chem Lett. 2020 Nov 12;11(11):2051-2052. doi: 10.1021/acsmedchemlett.0c00549. eCollection 2020 Nov 12. ACS Med Chem Lett. 2020. PMID: 33214806 Free PMC article. No abstract available.

10

A Mass Spectrometric Assay of METTL3/METTL14 Methyltransferase Activity.

Buker SM, Gurard-Levin ZA, Wheeler BD, Scholle MD, Case AW, Hirsch JL, Ribich S, Copeland RA, Boriack-Sjodin PA. Buker SM, et al. Among authors: copeland ra. SLAS Discov. 2020 Apr;25(4):361-371. doi: 10.1177/2472555219878408. Epub 2019 Oct 4. SLAS Discov. 2020. PMID: 31585521 Free article.

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