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High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition.
Cai J, Jacob S, Kurupi R, Dalton KM, Coon C, Greninger P, Egan RK, Stein GT, Murchie E, McClanaghan J, Adachi Y, Hirade K, Dozmorov M, Glod J, Boikos SA, Ebi H, Hao H, Caponigro G, Benes CH, Faber AC. Cai J, et al. Among authors: coon c. Cell Rep. 2022 Jul 26;40(4):111095. doi: 10.1016/j.celrep.2022.111095. Cell Rep. 2022. PMID: 35905710 Free PMC article.
Increased Synthesis of MCL-1 Protein Underlies Initial Survival of EGFR-Mutant Lung Cancer to EGFR Inhibitors and Provides a Novel Drug Target.
Song KA, Hosono Y, Turner C, Jacob S, Lochmann TL, Murakami Y, Patel NU, Ham J, Hu B, Powell KM, Coon CM, Windle BE, Oya Y, Koblinski JE, Harada H, Leverson JD, Souers AJ, Hata AN, Boikos S, Yatabe Y, Ebi H, Faber AC. Song KA, et al. Among authors: coon cm. Clin Cancer Res. 2018 Nov 15;24(22):5658-5672. doi: 10.1158/1078-0432.CCR-18-0304. Epub 2018 Aug 7. Clin Cancer Res. 2018. PMID: 30087143
The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity.
Heisey DAR, Lochmann TL, Floros KV, Coon CM, Powell KM, Jacob S, Calbert ML, Ghotra MS, Stein GT, Maves YK, Smith SC, Benes CH, Leverson JD, Souers AJ, Boikos SA, Faber AC. Heisey DAR, et al. Among authors: coon cm. Clin Cancer Res. 2019 Mar 1;25(5):1664-1675. doi: 10.1158/1078-0432.CCR-18-0277. Epub 2018 Oct 22. Clin Cancer Res. 2019. PMID: 30348635
MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis.
Floros KV, Cai J, Jacob S, Kurupi R, Fairchild CK, Shende M, Coon CM, Powell KM, Belvin BR, Hu B, Puchalapalli M, Ramamoorthy S, Swift K, Lewis JP, Dozmorov MG, Glod J, Koblinski JE, Boikos SA, Faber AC. Floros KV, et al. Among authors: coon cm. Cancer Res. 2021 Apr 1;81(7):1896-1908. doi: 10.1158/0008-5472.CAN-20-1641. Epub 2021 Jan 22. Cancer Res. 2021. PMID: 33483374 Free PMC article.
Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA.
Fairchild CK Jr, Floros KV, Jacob S, Coon CM, Puchalapalli M, Hu B, Harada H, Dozmorov MG, Koblinski JE, Smith SC, Domson G, Leverson JD, Souers AJ, Takebe N, Ebi H, Faber AC, Boikos SA. Fairchild CK Jr, et al. Among authors: coon cm. Cancers (Basel). 2021 May 12;13(10):2310. doi: 10.3390/cancers13102310. Cancers (Basel). 2021. PMID: 34065859 Free PMC article.
Venetoclax-based Rational Combinations are Effective in Models of MYCN-amplified Neuroblastoma.
Dalton KM, Krytska K, Lochmann TL, Sano R, Casey C, D'Aulerio A, Khan QA, Crowther GS, Coon C, Cai J, Jacob S, Kurupi R, Hu B, Dozmorov M, Greninger P, Souers AJ, Benes CH, Mossé YP, Faber AC. Dalton KM, et al. Among authors: coon c. Mol Cancer Ther. 2021 Aug;20(8):1400-1411. doi: 10.1158/1535-7163.MCT-20-0710. Epub 2021 Jun 4. Mol Cancer Ther. 2021. PMID: 34088831 Free PMC article.
Pharmacologic Inhibition of SHP2 Blocks Both PI3K and MEK Signaling in Low-epiregulin HNSCC via GAB1.
Kurupi R, Floros KV, Jacob S, Chawla AT, Cai J, Hu B, Puchalapalli M, Coon CM, Khatri R, Crowther GS, Egan RK, Murchie E, Greninger P, Dalton KM, Ghotra MS, Boikos SA, Koblinski JE, Harada H, Sun Y, Morgan IM, Basu D, Dozmorov MG, Benes CH, Faber AC. Kurupi R, et al. Among authors: coon cm. Cancer Res Commun. 2022 Sep;2(9):1061-1074. doi: 10.1158/2767-9764.crc-21-0137. Epub 2022 Sep 26. Cancer Res Commun. 2022. PMID: 36506869 Free PMC article.
Genomic screening reveals ubiquitin-like modifier activating enzyme 1 as a potent and druggable target in c-MYC-high triple negative breast cancer models.
Jacob S, Turner TH, Cai J, Floros KV, Yu AK, Coon CM, Khatri R, Alzubi MA, Jakubik CT, Bouck YM, Puchalapalli M, Shende M, Dozmorov MG, Boikos SA, Hu B, Harrell JC, Benes CH, Koblinski JE, Costa C, Faber AC. Jacob S, et al. Among authors: coon cm. PNAS Nexus. 2022 Oct 11;1(5):pgac232. doi: 10.1093/pnasnexus/pgac232. eCollection 2022 Nov. PNAS Nexus. 2022. PMID: 36712364 Free PMC article.
Mammal responses to global changes in human activity vary by trophic group and landscape.
Burton AC, Beirne C, Gaynor KM, Sun C, Granados A, Allen ML, Alston JM, Alvarenga GC, Calderón FSÁ, Amir Z, Anhalt-Depies C, Appel C, Arroyo-Arce S, Balme G, Bar-Massada A, Barcelos D, Barr E, Barthelmess EL, Baruzzi C, Basak SM, Beenaerts N, Belmaker J, Belova O, Bezarević B, Bird T, Bogan DA, Bogdanović N, Boyce A, Boyce M, Brandt L, Brodie JF, Brooke J, Bubnicki JW, Cagnacci F, Carr BS, Carvalho J, Casaer J, Černe R, Chen R, Chow E, Churski M, Cincotta C, Ćirović D, Coates TD, Compton J, Coon C, Cove MV, Crupi AP, Farra SD, Darracq AK, Davis M, Dawe K, De Waele V, Descalzo E, Diserens TA, Drimaj J, Duľa M, Ellis-Felege S, Ellison C, Ertürk A, Fantle-Lepczyk J, Favreau J, Fennell M, Ferreras P, Ferretti F, Fiderer C, Finnegan L, Fisher JT, Fisher-Reid MC, Flaherty EA, Fležar U, Flousek J, Foca JM, Ford A, Franzetti B, Frey S, Fritts S, Frýbová Š, Furnas B, Gerber B, Geyle HM, Giménez DG, Giordano AJ, Gomercic T, Gompper ME, Gräbin DM, Gray M, Green A, Hagen R, Hagen RB, Hammerich S, Hanekom C, Hansen C, Hasstedt S, Hebblewhite M, Heurich M, Hofmeester TR, Hubbard T, Jachowski D, Jansen PA, Jaspers KJ, Jensen A, Jordan M, Kaizer MC, Kelly MJ, Kohl MT, Kramer-Schadt S, Krof… See abstract for full author list ➔ Burton AC, et al. Among authors: coon c. Nat Ecol Evol. 2024 May;8(5):924-935. doi: 10.1038/s41559-024-02363-2. Epub 2024 Mar 18. Nat Ecol Evol. 2024. PMID: 38499871 Free PMC article.
206 results