Cook GM - Search Results

1

MmpL3 inhibitors as antituberculosis drugs.

Shao M, McNeil M, Cook GM, Lu X. Shao M, et al. Among authors: cook gm. Eur J Med Chem. 2020 Aug 15;200:112390. doi: 10.1016/j.ejmech.2020.112390. Epub 2020 May 4. Eur J Med Chem. 2020. PMID: 32447196 Review.

2

The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria.

McNeil MB, Hampton HG, Hards KJ, Watson BN, Cook GM, Fineran PC. McNeil MB, et al. Among authors: cook gm. FEBS Lett. 2014 Jan 31;588(3):414-21. doi: 10.1016/j.febslet.2013.12.019. Epub 2013 Dec 25. FEBS Lett. 2014. PMID: 24374335 Free article.

3

Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis.

Dunn EA, Roxburgh M, Larsen L, Smith RA, McLellan AD, Heikal A, Murphy MP, Cook GM. Dunn EA, et al. Among authors: cook gm. Bioorg Med Chem. 2014 Oct 1;22(19):5320-8. doi: 10.1016/j.bmc.2014.07.050. Epub 2014 Aug 7. Bioorg Med Chem. 2014. PMID: 25150092

4

'Tethering' fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase.

Heikal A, Nakatani Y, Jiao W, Wilson C, Rennison D, Weimar MR, Parker EJ, Brimble MA, Cook GM. Heikal A, et al. Among authors: cook gm. Bioorg Med Chem Lett. 2018 Jul 15;28(13):2239-2243. doi: 10.1016/j.bmcl.2018.05.048. Epub 2018 May 26. Bioorg Med Chem Lett. 2018. PMID: 29859905

5

Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis.

Lu X, Williams Z, Hards K, Tang J, Cheung CY, Aung HL, Wang B, Liu Z, Hu X, Lenaerts A, Woolhiser L, Hastings C, Zhang X, Wang Z, Rhee K, Ding K, Zhang T, Cook GM. Lu X, et al. Among authors: cook gm. ACS Infect Dis. 2019 Feb 8;5(2):239-249. doi: 10.1021/acsinfecdis.8b00225. Epub 2018 Dec 11. ACS Infect Dis. 2019. PMID: 30485737

6

Utilization of CRISPR Interference To Validate MmpL3 as a Drug Target in Mycobacterium tuberculosis.

McNeil MB, Cook GM. McNeil MB, et al. Among authors: cook gm. Antimicrob Agents Chemother. 2019 Jul 25;63(8):e00629-19. doi: 10.1128/AAC.00629-19. Print 2019 Aug. Antimicrob Agents Chemother. 2019. PMID: 31160289 Free PMC article.

7

The synthesis and evaluation of quinolinequinones as anti-mycobacterial agents.

Santoso KT, Menorca A, Cheung CY, Cook GM, Stocker BL, Timmer MSM. Santoso KT, et al. Among authors: cook gm. Bioorg Med Chem. 2019 Aug 15;27(16):3532-3545. doi: 10.1016/j.bmc.2019.06.002. Epub 2019 Jun 1. Bioorg Med Chem. 2019. PMID: 31262663

8

Two for the price of one: Attacking the energetic-metabolic hub of mycobacteria to produce new chemotherapeutic agents.

Hards K, Adolph C, Harold LK, McNeil MB, Cheung CY, Jinich A, Rhee KY, Cook GM. Hards K, et al. Among authors: cook gm. Prog Biophys Mol Biol. 2020 May;152:35-44. doi: 10.1016/j.pbiomolbio.2019.11.003. Epub 2019 Nov 13. Prog Biophys Mol Biol. 2020. PMID: 31733221 Review.

9

Transcriptional Inhibition of the F₁F₀-Type ATP Synthase Has Bactericidal Consequences on the Viability of Mycobacteria.

McNeil MB, Ryburn HWK, Harold LK, Tirados JF, Cook GM. McNeil MB, et al. Among authors: cook gm. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00492-20. doi: 10.1128/AAC.00492-20. Print 2020 Jul 22. Antimicrob Agents Chemother. 2020. PMID: 32423951 Free PMC article.

10

Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors.

Nizi MG, Desantis J, Nakatani Y, Massari S, Mazzarella MA, Shetye G, Sabatini S, Barreca ML, Manfroni G, Felicetti T, Rushton-Green R, Hards K, Latacz G, Satała G, Bojarski AJ, Cecchetti V, Kolář MH, Handzlik J, Cook GM, Franzblau SG, Tabarrini O. Nizi MG, et al. Among authors: cook gm. Eur J Med Chem. 2020 Sep 1;201:112420. doi: 10.1016/j.ejmech.2020.112420. Epub 2020 Jun 5. Eur J Med Chem. 2020. PMID: 32526553

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