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Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation.
Chakkalakal SA, Uchibe K, Convente MR, Zhang D, Economides AN, Kaplan FS, Pacifici M, Iwamoto M, Shore EM. Chakkalakal SA, et al. Among authors: convente mr. J Bone Miner Res. 2016 Sep;31(9):1666-75. doi: 10.1002/jbmr.2820. Epub 2016 Mar 12. J Bone Miner Res. 2016. PMID: 26896819 Free PMC article.
An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva.
Chakkalakal SA, Zhang D, Culbert AL, Convente MR, Caron RJ, Wright AC, Maidment AD, Kaplan FS, Shore EM. Chakkalakal SA, et al. Among authors: convente mr. J Bone Miner Res. 2012 Aug;27(8):1746-56. doi: 10.1002/jbmr.1637. J Bone Miner Res. 2012. PMID: 22508565 Free PMC article.