Connell SR - Search Results

1

The Novel Aminomethylcycline Omadacycline Has High Specificity for the Primary Tetracycline-Binding Site on the Bacterial Ribosome.

Heidrich CG, Mitova S, Schedlbauer A, Connell SR, Fucini P, Steenbergen JN, Berens C. Heidrich CG, et al. Among authors: connell sr. Antibiotics (Basel). 2016 Sep 22;5(4):32. doi: 10.3390/antibiotics5040032. Antibiotics (Basel). 2016. PMID: 27669321 Free PMC article.

2

Three-dimensional structures of translating ribosomes by Cryo-EM.

Gilbert RJ, Fucini P, Connell S, Fuller SD, Nierhaus KH, Robinson CV, Dobson CM, Stuart DI. Gilbert RJ, et al. Mol Cell. 2004 Apr 9;14(1):57-66. doi: 10.1016/s1097-2765(04)00163-7. Mol Cell. 2004. PMID: 15068803 Free article.

3

Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors.

Connell SR, Takemoto C, Wilson DN, Wang H, Murayama K, Terada T, Shirouzu M, Rost M, Schüler M, Giesebrecht J, Dabrowski M, Mielke T, Fucini P, Yokoyama S, Spahn CM. Connell SR, et al. Mol Cell. 2007 Mar 9;25(5):751-64. doi: 10.1016/j.molcel.2007.01.027. Mol Cell. 2007. PMID: 17349960 Free article.

4

Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin.

Harms JM, Wilson DN, Schluenzen F, Connell SR, Stachelhaus T, Zaborowska Z, Spahn CM, Fucini P. Harms JM, et al. Among authors: connell sr. Mol Cell. 2008 Apr 11;30(1):26-38. doi: 10.1016/j.molcel.2008.01.009. Mol Cell. 2008. PMID: 18406324 Free article.

5

A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation.

Connell SR, Topf M, Qin Y, Wilson DN, Mielke T, Fucini P, Nierhaus KH, Spahn CM. Connell SR, et al. Nat Struct Mol Biol. 2008 Sep;15(9):910-5. doi: 10.1038/nsmb.1469. Nat Struct Mol Biol. 2008. PMID: 19172743

6

Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites.

Ratje AH, Loerke J, Mikolajka A, Brünner M, Hildebrand PW, Starosta AL, Dönhöfer A, Connell SR, Fucini P, Mielke T, Whitford PC, Onuchic JN, Yu Y, Sanbonmatsu KY, Hartmann RK, Penczek PA, Wilson DN, Spahn CM. Ratje AH, et al. Among authors: connell sr. Nature. 2010 Dec 2;468(7324):713-6. doi: 10.1038/nature09547. Nature. 2010. PMID: 21124459 Free PMC article.

7

Solid-state NMR enhanced by dynamic nuclear polarization as a novel tool for ribosome structural biology.

Gelis I, Vitzthum V, Dhimole N, Caporini MA, Schedlbauer A, Carnevale D, Connell SR, Fucini P, Bodenhausen G. Gelis I, et al. Among authors: connell sr. J Biomol NMR. 2013 Jun;56(2):85-93. doi: 10.1007/s10858-013-9721-2. Epub 2013 May 21. J Biomol NMR. 2013. PMID: 23689811

8

Structural characterization of an alternative mode of tigecycline binding to the bacterial ribosome.

Schedlbauer A, Kaminishi T, Ochoa-Lizarralde B, Dhimole N, Zhou S, López-Alonso JP, Connell SR, Fucini P. Schedlbauer A, et al. Among authors: connell sr. Antimicrob Agents Chemother. 2015 May;59(5):2849-54. doi: 10.1128/AAC.04895-14. Epub 2015 Mar 9. Antimicrob Agents Chemother. 2015. PMID: 25753625 Free PMC article.

9

Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.

Kaminishi T, Schedlbauer A, Fabbretti A, Brandi L, Ochoa-Lizarralde B, He CG, Milón P, Connell SR, Gualerzi CO, Fucini P. Kaminishi T, et al. Among authors: connell sr. Nucleic Acids Res. 2015 Nov 16;43(20):10015-25. doi: 10.1093/nar/gkv975. Epub 2015 Oct 12. Nucleic Acids Res. 2015. PMID: 26464437 Free PMC article.

10

Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding.

Fabbretti A, Schedlbauer A, Brandi L, Kaminishi T, Giuliodori AM, Garofalo R, Ochoa-Lizarralde B, Takemoto C, Yokoyama S, Connell SR, Gualerzi CO, Fucini P. Fabbretti A, et al. Among authors: connell sr. Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2286-95. doi: 10.1073/pnas.1521156113. Epub 2016 Apr 6. Proc Natl Acad Sci U S A. 2016. PMID: 27071098 Free PMC article.

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