Colombo A - Search Results

1

BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.

Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, Kuhn PH, Colombo A, Havas D, Flunkert S, McDonald J, Gunnersen JM, Hutter-Paier B, Tahirovic S, Windisch M, Krainc D, Lichtenthaler SF, Hecimovic S. Causevic M, et al. Among authors: colombo a. PLoS One. 2018 Jul 6;13(7):e0200344. doi: 10.1371/journal.pone.0200344. eCollection 2018. PLoS One. 2018. PMID: 29979789 Free PMC article.

2

Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.

Hogl S, Kuhn PH, Colombo A, Lichtenthaler SF. Hogl S, et al. Among authors: colombo a. PLoS One. 2011;6(6):e21337. doi: 10.1371/journal.pone.0021337. Epub 2011 Jun 17. PLoS One. 2011. PMID: 21695060 Free PMC article.

3

Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation.

Dominko K, Rastija A, Sobocanec S, Vidatic L, Meglaj S, Lovincic Babic A, Hutter-Paier B, Colombo AV, Lichtenthaler SF, Tahirovic S, Hecimovic S. Dominko K, et al. Among authors: colombo av. Int J Mol Sci. 2021 Dec 9;22(24):13256. doi: 10.3390/ijms222413256. Int J Mol Sci. 2021. PMID: 34948052 Free PMC article.

4

In vivo Ca²⁺ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria.

Montagna E, Crux S, Luckner M, Herber J, Colombo AV, Marinković P, Tahirovic S, Lichtenthaler SF, Wanner G, Müller UC, Sgobio C, Herms J. Montagna E, et al. Glia. 2019 May;67(5):985-998. doi: 10.1002/glia.23584. Epub 2019 Jan 22. Glia. 2019. PMID: 30667091

5

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function.

Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Müller U, Schweizer M, Saftig P, Bräse S, Lichtenthaler SF. Kuhn PH, et al. Among authors: colombo av. Elife. 2016 Jan 23;5:e12748. doi: 10.7554/eLife.12748. Elife. 2016. PMID: 26802628 Free PMC article.

6

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models.

Sebastian Monasor L, Müller SA, Colombo AV, Tanrioever G, König J, Roth S, Liesz A, Berghofer A, Piechotta A, Prestel M, Saito T, Saido TC, Herms J, Willem M, Haass C, Lichtenthaler SF, Tahirovic S. Sebastian Monasor L, et al. Among authors: colombo av. Elife. 2020 Jun 8;9:e54083. doi: 10.7554/eLife.54083. Elife. 2020. PMID: 32510331 Free PMC article.

7

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia.

Colombo A, Dinkel L, Müller SA, Sebastian Monasor L, Schifferer M, Cantuti-Castelvetri L, König J, Vidatic L, Bremova-Ertl T, Lieberman AP, Hecimovic S, Simons M, Lichtenthaler SF, Strupp M, Schneider SA, Tahirovic S. Colombo A, et al. Nat Commun. 2021 Feb 24;12(1):1158. doi: 10.1038/s41467-021-21428-5. Nat Commun. 2021. PMID: 33627648 Free PMC article.

8

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.

Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF. Kuhn PH, et al. Among authors: colombo a. EMBO J. 2012 Jun 22;31(14):3157-68. doi: 10.1038/emboj.2012.173. EMBO J. 2012. PMID: 22728825 Free PMC article.

9

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.

Colombo A, Wang H, Kuhn PH, Page R, Kremmer E, Dempsey PJ, Crawford HC, Lichtenthaler SF. Colombo A, et al. Neurobiol Dis. 2013 Jan;49:137-47. doi: 10.1016/j.nbd.2012.08.011. Epub 2012 Aug 24. Neurobiol Dis. 2013. PMID: 22940630 Free PMC article.

10

Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.

Fleck D, van Bebber F, Colombo A, Galante C, Schwenk BM, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C. Fleck D, et al. Among authors: colombo a. J Neurosci. 2013 May 1;33(18):7856-69. doi: 10.1523/JNEUROSCI.3372-12.2013. J Neurosci. 2013. PMID: 23637177 Free PMC article.

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