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The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis.
Andreuzzi E, Colladel R, Pellicani R, Tarticchio G, Cannizzaro R, Spessotto P, Bussolati B, Brossa A, De Paoli P, Canzonieri V, Iozzo RV, Colombatti A, Mongiat M. Andreuzzi E, et al. Among authors: colombatti a. Matrix Biol. 2017 Dec;64:40-53. doi: 10.1016/j.matbio.2017.04.002. Epub 2017 Apr 21. Matrix Biol. 2017. PMID: 28435016 Free article.
Multimerin-2 maintains vascular stability and permeability.
Pellicani R, Poletto E, Andreuzzi E, Paulitti A, Doliana R, Bizzotto D, Braghetta P, Colladel R, Tarticchio G, Sabatelli P, Bucciotti F, Bressan G, Iozzo RV, Colombatti A, Bonaldo P, Mongiat M. Pellicani R, et al. Among authors: colombatti a. Matrix Biol. 2020 May;87:11-25. doi: 10.1016/j.matbio.2019.08.002. Epub 2019 Aug 15. Matrix Biol. 2020. PMID: 31422156 Free article.
The EMILIN/Multimerin family.
Colombatti A, Spessotto P, Doliana R, Mongiat M, Bressan GM, Esposito G. Colombatti A, et al. Front Immunol. 2012 Jan 6;2:93. doi: 10.3389/fimmu.2011.00093. eCollection 2011. Front Immunol. 2012. PMID: 22566882 Free PMC article.
The ablation of the matricellular protein EMILIN2 causes defective vascularization due to impaired EGFR-dependent IL-8 production affecting tumor growth.
Paulitti A, Andreuzzi E, Bizzotto D, Pellicani R, Tarticchio G, Marastoni S, Pastrello C, Jurisica I, Ligresti G, Bucciotti F, Doliana R, Colladel R, Braghetta P, Poletto E, Di Silvestre A, Bressan G, Colombatti A, Bonaldo P, Mongiat M. Paulitti A, et al. Among authors: colombatti a. Oncogene. 2018 Jun;37(25):3399-3414. doi: 10.1038/s41388-017-0107-x. Epub 2018 Feb 27. Oncogene. 2018. PMID: 29483644
Abrogation of EMILIN1-β1 integrin interaction promotes experimental colitis and colon carcinogenesis.
Capuano A, Pivetta E, Sartori G, Bosisio G, Favero A, Cover E, Andreuzzi E, Colombatti A, Cannizzaro R, Scanziani E, Minoli L, Bucciotti F, Amor Lopez AI, Gaspardo K, Doliana R, Mongiat M, Spessotto P. Capuano A, et al. Among authors: colombatti a. Matrix Biol. 2019 Oct;83:97-115. doi: 10.1016/j.matbio.2019.08.006. Epub 2019 Aug 31. Matrix Biol. 2019. PMID: 31479698 Free article.
Colorectal cancer development is affected by the ECM molecule EMILIN-2 hinging on macrophage polarization via the TLR-4/MyD88 pathway.
Andreuzzi E, Fejza A, Polano M, Poletto E, Camicia L, Carobolante G, Tarticchio G, Todaro F, Di Carlo E, Scarpa M, Scarpa M, Paulitti A, Capuano A, Canzonieri V, Maiero S, Fornasarig M, Cannizzaro R, Doliana R, Colombatti A, Spessotto P, Mongiat M. Andreuzzi E, et al. Among authors: colombatti a. J Exp Clin Cancer Res. 2022 Feb 11;41(1):60. doi: 10.1186/s13046-022-02271-y. J Exp Clin Cancer Res. 2022. PMID: 35148799 Free PMC article.
The EMILIN protein family.
Colombatti A, Doliana R, Bot S, Canton A, Mongiat M, Mungiguerra G, Paron-Cilli S, Spessotto P. Colombatti A, et al. Matrix Biol. 2000 Aug;19(4):289-301. doi: 10.1016/s0945-053x(00)00074-3. Matrix Biol. 2000. PMID: 10963989 Review.
232 results