Colca JR - Search Results

1

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19.

Zhu B, Wei X, Narasimhan H, Qian W, Zhang R, Cheon IS, Wu Y, Li C, Jones RG, Kaplan MH, Vassallo RA, Braciale TJ, Somerville L, Colca JR, Pandey A, Jackson PEH, Mann BJ, Krawczyk CM, Sturek JM, Sun J. Zhu B, et al. Among authors: colca jr. Sci Immunol. 2023 Apr 14;8(82):eadf0348. doi: 10.1126/sciimmunol.adf0348. Epub 2023 Apr 14. Sci Immunol. 2023. PMID: 36821695 Free PMC article.

2

Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism.

Ferguson D, Eichler SJ, Yiew NKH, Colca JR, Cho K, Patti GJ, Shew TM, Lutkewitte AJ, Mukherjee S, McCommis KS, Niemi NM, Finck BN. Ferguson D, et al. Among authors: colca jr. Mol Metab. 2023 Apr;70:101694. doi: 10.1016/j.molmet.2023.101694. Epub 2023 Feb 18. Mol Metab. 2023. PMID: 36801448 Free PMC article. Clinical Trial.

3

Insulin sensitizers in 2023: lessons learned and new avenues for investigation.

Colca JR, Tanis SP, Kletzien RF, Finck BN. Colca JR, et al. Expert Opin Investig Drugs. 2023 Jul-Dec;32(9):803-811. doi: 10.1080/13543784.2023.2263369. Epub 2023 Oct 13. Expert Opin Investig Drugs. 2023. PMID: 37755339 Review.

4

Hyperinsulinemia, an overlooked clue and potential way forward in metabolic dysfunction-associated steatotic liver disease.

Harrison SA, Dubourg J, Knott M, Colca J. Harrison SA, et al. Hepatology. 2023 Dec 5. doi: 10.1097/HEP.0000000000000710. Online ahead of print. Hepatology. 2023. PMID: 38051957

5

Re-routing Metabolism by the Mitochondrial Pyruvate Carrier Inhibitor MSDC-0160 Attenuates Neurodegeneration in a Rat Model of Parkinson's Disease.

Mallet D, Goutaudier R, Barbier EL, Carnicella S, Colca JR, Fauvelle F, Boulet S. Mallet D, et al. Among authors: colca jr. Mol Neurobiol. 2022 Oct;59(10):6170-6182. doi: 10.1007/s12035-022-02962-9. Epub 2022 Jul 27. Mol Neurobiol. 2022. PMID: 35895232

6

Metabolic Mechanisms Connecting Alzheimer's and Parkinson's Diseases: Potential Avenues for Novel Therapeutic Approaches.

Colca JR, Finck BN. Colca JR, et al. Front Mol Biosci. 2022 Jun 16;9:929328. doi: 10.3389/fmolb.2022.929328. eCollection 2022. Front Mol Biosci. 2022. PMID: 35782864 Free PMC article. Review.

7

The metabolic syndrome, thiazolidinediones, and implications for intersection of chronic and inflammatory disease.

Colca JR, Scherer PE. Colca JR, et al. Mol Metab. 2022 Jan;55:101409. doi: 10.1016/j.molmet.2021.101409. Epub 2021 Dec 1. Mol Metab. 2022. PMID: 34863942 Free PMC article. Review.

8

Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide.

Kamm DR, Pyles KD, Sharpe MC, Healy LN, Colca JR, McCommis KS. Kamm DR, et al. Among authors: colca jr. J Biol Chem. 2021 Jan-Jun;296:100807. doi: 10.1016/j.jbc.2021.100807. Epub 2021 May 20. J Biol Chem. 2021. PMID: 34022222 Free PMC article.

9

Suboptimal reliability of liver biopsy evaluation has implications for randomized clinical trials.

Davison BA, Harrison SA, Cotter G, Alkhouri N, Sanyal A, Edwards C, Colca JR, Iwashita J, Koch GG, Dittrich HC. Davison BA, et al. Among authors: colca jr. J Hepatol. 2020 Dec;73(6):1322-1332. doi: 10.1016/j.jhep.2020.06.025. Epub 2020 Jun 28. J Hepatol. 2020. PMID: 32610115 Clinical Trial.

10

Inhibiting the mitochondrial pyruvate carrier does not ameliorate synucleinopathy in the absence of inflammation or metabolic deficits.

Peelaerts W, Bergkvist L, George S, Johnson M, Meyerdirk L, Schulz E, Steiner JA, Madaj Z, Ma J, Becker K, Nilsson KPR, Colca JR, Brundin P. Peelaerts W, et al. Among authors: colca jr. Free Neuropathol. 2020;1:1-33. doi: 10.17879/freeneuropathology-2020-3049. Epub 2020 Nov 25. Free Neuropathol. 2020. PMID: 35224554 Free PMC article.

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