Cohen MS - Search Results

1

Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.

Arnold MR, Langelier MF, Gartrell J, Kirby IT, Sanderson DJ, Bejan DS, Šileikytė J, Sundalam SK, Nagarajan S, Marimuthu P, Duell AK, Shelat AA, Pascal JM, Cohen MS. Arnold MR, et al. Among authors: cohen ms. Cell Chem Biol. 2022 Dec 15;29(12):1694-1708.e10. doi: 10.1016/j.chembiol.2022.11.006. Epub 2022 Dec 8. Cell Chem Biol. 2022. PMID: 36493759 Free article.

2

Selective inhibition of PARP10 using a chemical genetics strategy.

Morgan RK, Carter-O'Connell I, Cohen MS. Morgan RK, et al. Among authors: cohen ms. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4770-4773. doi: 10.1016/j.bmcl.2015.07.033. Epub 2015 Jul 17. Bioorg Med Chem Lett. 2015. PMID: 26231158 Free PMC article.

3

Identifying Direct Protein Targets of Poly-ADP-Ribose Polymerases (PARPs) Using Engineered PARP Variants-Orthogonal Nicotinamide Adenine Dinucleotide (NAD+) Analog Pairs.

Carter-O'Connell I, Cohen MS. Carter-O'Connell I, et al. Among authors: cohen ms. Curr Protoc Chem Biol. 2015 Jun 1;7(2):121-39. doi: 10.1002/9780470559277.ch140259. Curr Protoc Chem Biol. 2015. PMID: 26344237 Free PMC article.

4

Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.

Thorsell AG, Ekblad T, Karlberg T, Löw M, Pinto AF, Trésaugues L, Moche M, Cohen MS, Schüler H. Thorsell AG, et al. Among authors: cohen ms. J Med Chem. 2017 Feb 23;60(4):1262-1271. doi: 10.1021/acs.jmedchem.6b00990. Epub 2016 Dec 21. J Med Chem. 2017. PMID: 28001384 Free PMC article.

5

Insights into the biogenesis, function, and regulation of ADP-ribosylation.

Cohen MS, Chang P. Cohen MS, et al. Nat Chem Biol. 2018 Feb 14;14(3):236-243. doi: 10.1038/nchembio.2568. Nat Chem Biol. 2018. PMID: 29443986 Free PMC article. Review.

6

A Simple, Sensitive, and Generalizable Plate Assay for Screening PARP Inhibitors.

Kirby IT, Morgan RK, Cohen MS. Kirby IT, et al. Among authors: cohen ms. Methods Mol Biol. 2018;1813:245-252. doi: 10.1007/978-1-4939-8588-3_17. Methods Mol Biol. 2018. PMID: 30097873

7

Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics.

Kirby IT, Cohen MS. Kirby IT, et al. Among authors: cohen ms. Curr Top Microbiol Immunol. 2019;420:211-231. doi: 10.1007/82_2018_137. Curr Top Microbiol Immunol. 2019. PMID: 30242511 Review.

8

Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14).

Carter-O'Connell I, Vermehren-Schmaedick A, Jin H, Morgan RK, David LL, Cohen MS. Carter-O'Connell I, et al. Among authors: cohen ms. ACS Chem Biol. 2018 Oct 19;13(10):2841-2848. doi: 10.1021/acschembio.8b00567. Epub 2018 Sep 28. ACS Chem Biol. 2018. PMID: 30247868

9

ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication.

Abraham R, Hauer D, McPherson RL, Utt A, Kirby IT, Cohen MS, Merits A, Leung AKL, Griffin DE. Abraham R, et al. Among authors: cohen ms. Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10457-E10466. doi: 10.1073/pnas.1812130115. Epub 2018 Oct 15. Proc Natl Acad Sci U S A. 2018. PMID: 30322911 Free PMC article.

10

A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity.

Kirby IT, Kojic A, Arnold MR, Thorsell AG, Karlberg T, Vermehren-Schmaedick A, Sreenivasan R, Schultz C, Schüler H, Cohen MS. Kirby IT, et al. Among authors: cohen ms. Cell Chem Biol. 2018 Dec 20;25(12):1547-1553.e12. doi: 10.1016/j.chembiol.2018.09.011. Epub 2018 Oct 18. Cell Chem Biol. 2018. PMID: 30344052 Free article.

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