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LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.
Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V. Simon M, et al. Among authors: cohen hy. Cell Metab. 2019 Apr 2;29(4):871-885.e5. doi: 10.1016/j.cmet.2019.02.014. Epub 2019 Mar 7. Cell Metab. 2019. PMID: 30853213 Free PMC article.
Multiple regulatory layers of SREBP1/2 by SIRT6.
Elhanati S, Kanfi Y, Varvak A, Roichman A, Carmel-Gross I, Barth S, Gibor G, Cohen HY. Elhanati S, et al. Among authors: cohen hy. Cell Rep. 2013 Sep 12;4(5):905-12. doi: 10.1016/j.celrep.2013.08.006. Epub 2013 Sep 5. Cell Rep. 2013. PMID: 24012758 Free article.
SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan.
Roichman A, Kanfi Y, Glazz R, Naiman S, Amit U, Landa N, Tinman S, Stein I, Pikarsky E, Leor J, Cohen HY. Roichman A, et al. Among authors: cohen hy. J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):603-615. doi: 10.1093/gerona/glw152. J Gerontol A Biol Sci Med Sci. 2017. PMID: 27519885
Characterization of physiological defects in adult SIRT6-/- mice.
Peshti V, Obolensky A, Nahum L, Kanfi Y, Rathaus M, Avraham M, Tinman S, Alt FW, Banin E, Cohen HY. Peshti V, et al. Among authors: cohen hy. PLoS One. 2017 Apr 27;12(4):e0176371. doi: 10.1371/journal.pone.0176371. eCollection 2017. PLoS One. 2017. PMID: 28448551 Free PMC article.
SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα.
Naiman S, Huynh FK, Gil R, Glick Y, Shahar Y, Touitou N, Nahum L, Avivi MY, Roichman A, Kanfi Y, Gertler AA, Doniger T, Ilkayeva OR, Abramovich I, Yaron O, Lerrer B, Gottlieb E, Harris RA, Gerber D, Hirschey MD, Cohen HY. Naiman S, et al. Among authors: cohen hy. Cell Rep. 2019 Dec 17;29(12):4127-4143.e8. doi: 10.1016/j.celrep.2019.11.067. Cell Rep. 2019. PMID: 31851938 Free PMC article.
Restoration of energy homeostasis by SIRT6 extends healthy lifespan.
Roichman A, Elhanati S, Aon MA, Abramovich I, Di Francesco A, Shahar Y, Avivi MY, Shurgi M, Rubinstein A, Wiesner Y, Shuchami A, Petrover Z, Lebenthal-Loinger I, Yaron O, Lyashkov A, Ubaida-Mohien C, Kanfi Y, Lerrer B, Fernández-Marcos PJ, Serrano M, Gottlieb E, de Cabo R, Cohen HY. Roichman A, et al. Among authors: cohen hy. Nat Commun. 2021 May 28;12(1):3208. doi: 10.1038/s41467-021-23545-7. Nat Commun. 2021. PMID: 34050173 Free PMC article.
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