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Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Sola I, Castellà S, Viayna E, Galdeano C, Taylor MC, Gbedema SY, Pérez B, Clos MV, Jones DC, Fairlamb AH, Wright CW, Kelly JM, Muñoz-Torrero D. Sola I, et al. Among authors: clos mv. Bioorg Med Chem. 2015 Aug 15;23(16):5156-67. doi: 10.1016/j.bmc.2015.01.031. Epub 2015 Jan 24. Bioorg Med Chem. 2015. PMID: 25678015
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.
Galdeano C, Viayna E, Sola I, Formosa X, Camps P, Badia A, Clos MV, Relat J, Ratia M, Bartolini M, Mancini F, Andrisano V, Salmona M, Minguillón C, González-Muñoz GC, Rodríguez-Franco MI, Bidon-Chanal A, Luque FJ, Muñoz-Torrero D. Galdeano C, et al. Among authors: clos mv. J Med Chem. 2012 Jan 26;55(2):661-9. doi: 10.1021/jm200840c. Epub 2012 Jan 10. J Med Chem. 2012. PMID: 22185619
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.
Di Pietro O, Viayna E, Vicente-García E, Bartolini M, Ramón R, Juárez-Jiménez J, Clos MV, Pérez B, Andrisano V, Luque FJ, Lavilla R, Muñoz-Torrero D. Di Pietro O, et al. Among authors: clos mv. Eur J Med Chem. 2014 Feb 12;73:141-52. doi: 10.1016/j.ejmech.2013.12.008. Epub 2013 Dec 18. Eur J Med Chem. 2014. PMID: 24389509 Free article.
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.
Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabaté R, Juárez-Jiménez J, Pérez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Muñoz-Torrero D. Viayna E, et al. Among authors: clos mv. J Med Chem. 2014 Mar 27;57(6):2549-67. doi: 10.1021/jm401824w. Epub 2014 Mar 10. J Med Chem. 2014. PMID: 24568372 Free article.
Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.
Pérez-Areales FJ, Di Pietro O, Espargaró A, Vallverdú-Queralt A, Galdeano C, Ragusa IM, Viayna E, Guillou C, Clos MV, Pérez B, Sabaté R, Lamuela-Raventós RM, Luque FJ, Muñoz-Torrero D. Pérez-Areales FJ, et al. Among authors: clos mv. Bioorg Med Chem. 2014 Oct 1;22(19):5298-307. doi: 10.1016/j.bmc.2014.07.053. Epub 2014 Aug 7. Bioorg Med Chem. 2014. PMID: 25156301
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.
Di Pietro O, Vicente-García E, Taylor MC, Berenguer D, Viayna E, Lanzoni A, Sola I, Sayago H, Riera C, Fisa R, Clos MV, Pérez B, Kelly JM, Lavilla R, Muñoz-Torrero D. Di Pietro O, et al. Among authors: clos mv. Eur J Med Chem. 2015 Nov 13;105:120-37. doi: 10.1016/j.ejmech.2015.10.007. Epub 2015 Oct 19. Eur J Med Chem. 2015. PMID: 26479031 Free PMC article.
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
Sola I, Artigas A, Taylor MC, Pérez-Areales FJ, Viayna E, Clos MV, Pérez B, Wright CW, Kelly JM, Muñoz-Torrero D. Sola I, et al. Among authors: clos mv. Bioorg Med Chem. 2016 Nov 1;24(21):5162-5171. doi: 10.1016/j.bmc.2016.08.036. Epub 2016 Aug 22. Bioorg Med Chem. 2016. PMID: 27591008 Free PMC article.
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Camps P, Formosa X, Galdeano C, Gómez T, Muñoz-Torrero D, Scarpellini M, Viayna E, Badia A, Clos MV, Camins A, Pallàs M, Bartolini M, Mancini F, Andrisano V, Estelrich J, Lizondo M, Bidon-Chanal A, Luque FJ. Camps P, et al. Among authors: clos mv. J Med Chem. 2008 Jun 26;51(12):3588-98. doi: 10.1021/jm8001313. Epub 2008 Jun 3. J Med Chem. 2008. PMID: 18517184
46 results