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Glycoengineered recombinant alpha1-antitrypsin results in comparable in vitro and in vivo activities to human plasma-derived protein.
Rocamora F, Schoffelen S, Arnsdorf J, Toth EA, Abdul Y, Cleveland TE 4th, Bjørn SP, Wu MYM, McElvaney NG, Voldborg BGR, Fuerst TR, Lewis NE. Rocamora F, et al. Among authors: cleveland te 4th. bioRxiv [Preprint]. 2024 Mar 30:2024.03.27.587088. doi: 10.1101/2024.03.27.587088. bioRxiv. 2024. PMID: 38585818 Free PMC article. Preprint.
A round-robin approach provides a detailed assessment of biomolecular small-angle scattering data reproducibility and yields consensus curves for benchmarking.
Trewhella J, Vachette P, Bierma J, Blanchet C, Brookes E, Chakravarthy S, Chatzimagas L, Cleveland TE 4th, Cowieson N, Crossett B, Duff AP, Franke D, Gabel F, Gillilan RE, Graewert M, Grishaev A, Guss JM, Hammel M, Hopkins J, Huang Q, Hub JS, Hura GL, Irving TC, Jeffries CM, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic I, Rocco M, Rosenberg DJ, Ryan TM, Seifert S, Sekiguchi H, Svergun D, Teixeira S, Thureau A, Weiss TM, Whitten AE, Wood K, Zuo X. Trewhella J, et al. Among authors: cleveland te 4th. Acta Crystallogr D Struct Biol. 2022 Nov 1;78(Pt 11):1315-1336. doi: 10.1107/S2059798322009184. Epub 2022 Oct 20. Acta Crystallogr D Struct Biol. 2022. PMID: 36322416 Free PMC article.
Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer.
Guest JD, Wang R, Elkholy KH, Chagas A, Chao KL, Cleveland TE 4th, Kim YC, Keck ZY, Marin A, Yunus AS, Mariuzza RA, Andrianov AK, Toth EA, Foung SKH, Pierce BG, Fuerst TR. Guest JD, et al. Among authors: cleveland te 4th. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2015149118. doi: 10.1073/pnas.2015149118. Proc Natl Acad Sci U S A. 2021. PMID: 33431677 Free PMC article.
A single ligand is sufficient to activate EGFR dimers.
Liu P, Cleveland TE 4th, Bouyain S, Byrne PO, Longo PA, Leahy DJ. Liu P, et al. Among authors: cleveland te 4th. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10861-6. doi: 10.1073/pnas.1201114109. Epub 2012 Jun 14. Proc Natl Acad Sci U S A. 2012. PMID: 22699492 Free PMC article.