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Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity.
Borodovsky A, Barbon CM, Wang Y, Ye M, Prickett L, Chandra D, Shaw J, Deng N, Sachsenmeier K, Clarke JD, Linghu B, Brown GA, Brown J, Congreve M, Cheng RK, Dore AS, Hurrell E, Shao W, Woessner R, Reimer C, Drew L, Fawell S, Schuller AG, Mele DA. Borodovsky A, et al. Among authors: clarke jd. J Immunother Cancer. 2020 Jul;8(2):e000417. doi: 10.1136/jitc-2019-000417. J Immunother Cancer. 2020. PMID: 32727810 Free PMC article.
M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer.
Garrido-Martin EM, Mellows TWP, Clarke J, Ganesan AP, Wood O, Cazaly A, Seumois G, Chee SJ, Alzetani A, King EV, Hedrick CC, Thomas G, Friedmann PS, Ottensmeier CH, Vijayanand P, Sanchez-Elsner T. Garrido-Martin EM, et al. J Immunother Cancer. 2020 Jul;8(2):e000778. doi: 10.1136/jitc-2020-000778. J Immunother Cancer. 2020. PMID: 32699181 Free PMC article.
Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer.
Ganesan AP, Clarke J, Wood O, Garrido-Martin EM, Chee SJ, Mellows T, Samaniego-Castruita D, Singh D, Seumois G, Alzetani A, Woo E, Friedmann PS, King EV, Thomas GJ, Sanchez-Elsner T, Vijayanand P, Ottensmeier CH. Ganesan AP, et al. Nat Immunol. 2017 Aug;18(8):940-950. doi: 10.1038/ni.3775. Epub 2017 Jun 19. Nat Immunol. 2017. PMID: 28628092 Free PMC article.
Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy.
Eschweiler S, Clarke J, Ramírez-Suástegui C, Panwar B, Madrigal A, Chee SJ, Karydis I, Woo E, Alzetani A, Elsheikh S, Hanley CJ, Thomas GJ, Friedmann PS, Sanchez-Elsner T, Ay F, Ottensmeier CH, Vijayanand P. Eschweiler S, et al. Nat Immunol. 2021 Aug;22(8):1052-1063. doi: 10.1038/s41590-021-00958-6. Epub 2021 Jun 24. Nat Immunol. 2021. PMID: 34168370 Free PMC article.
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion.
Whiteside SK, Grant FM, Alvisi G, Clarke J, Tang L, Imianowski CJ, Zhang B, Evans AC, Wesolowski AJ, Conti AG, Yang J, Lauder SN, Clement M, Humphreys IR, Dooley J, Burton O, Liston A, Alloisio M, Voulaz E, Langhorne J, Okkenhaug K, Lugli E, Roychoudhuri R. Whiteside SK, et al. Sci Immunol. 2023 Dec 15;8(90):eabo5558. doi: 10.1126/sciimmunol.abo5558. Epub 2023 Dec 15. Sci Immunol. 2023. PMID: 38100544 Free PMC article.
Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer.
Clarke J, Panwar B, Madrigal A, Singh D, Gujar R, Wood O, Chee SJ, Eschweiler S, King EV, Awad AS, Hanley CJ, McCann KJ, Bhattacharyya S, Woo E, Alzetani A, Seumois G, Thomas GJ, Ganesan AP, Friedmann PS, Sanchez-Elsner T, Ay F, Ottensmeier CH, Vijayanand P. Clarke J, et al. J Exp Med. 2019 Sep 2;216(9):2128-2149. doi: 10.1084/jem.20190249. Epub 2019 Jun 21. J Exp Med. 2019. PMID: 31227543 Free PMC article.
196 results