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Chemical genetics of Plasmodium falciparum.
Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK. Guiguemde WA, et al. Among authors: clark j. Nature. 2010 May 20;465(7296):311-5. doi: 10.1038/nature09099. Nature. 2010. PMID: 20485428 Free PMC article.
Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum.
Zhang J, Bowling JJ, Smithson D, Clark J, Jacob MR, Khan SI, Tekwani BL, Connelly M, Samoylenko V, Ibrahim MA, Zaki MA, Wang M, Hester JP, Tu Y, Jeffries C, Twarog N, Shelat AA, Walker LA, Muhammad I, Guy RK. Zhang J, et al. Among authors: clark j. Malar J. 2016 May 10;15(1):270. doi: 10.1186/s12936-016-1313-7. Malar J. 2016. PMID: 27165106 Free PMC article.
Optimization of propafenone analogues as antimalarial leads.
Lowes DJ, Guiguemde WA, Connelly MC, Zhu F, Sigal MS, Clark JA, Lemoff AS, Derisi JL, Wilson EB, Guy RK. Lowes DJ, et al. Among authors: clark ja. J Med Chem. 2011 Nov 10;54(21):7477-85. doi: 10.1021/jm2005546. Epub 2011 Oct 10. J Med Chem. 2011. PMID: 21955244 Free PMC article.
Lead optimization of antimalarial propafenone analogues.
Lowes D, Pradhan A, Iyer LV, Parman T, Gow J, Zhu F, Furimsky A, Lemoff A, Guiguemde WA, Sigal M, Clark JA, Wilson E, Tang L, Connelly MC, Derisi JL, Kyle DE, Mirsalis J, Guy RK. Lowes D, et al. Among authors: clark ja. J Med Chem. 2012 Jul 12;55(13):6087-93. doi: 10.1021/jm300286a. Epub 2012 Jun 29. J Med Chem. 2012. PMID: 22708838 Free PMC article.
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.
Jiménez-Díaz MB, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O'Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, Endsley AN, Fedewa G, Guiguemde WA, Gómez MG, Holbrook G, Horst J, Kim CC, Liu J, Lee MC, Matheny A, Martínez MS, Miller G, Rodríguez-Alejandre A, Sanz L, Sigal M, Spillman NJ, Stein PD, Wang Z, Zhu F, Waterson D, Knapp S, Shelat A, Avery VM, Fidock DA, Gamo FJ, Charman SA, Mirsalis JC, Ma H, Ferrer S, Kirk K, Angulo-Barturen I, Kyle DE, DeRisi JL, Floyd DM, Guy RK. Jiménez-Díaz MB, et al. Among authors: clark ja. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5455-62. doi: 10.1073/pnas.1414221111. Epub 2014 Dec 1. Proc Natl Acad Sci U S A. 2014. PMID: 25453091 Free PMC article.
Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides.
Floyd DM, Stein P, Wang Z, Liu J, Castro S, Clark JA, Connelly M, Zhu F, Holbrook G, Matheny A, Sigal MS, Min J, Dhinakaran R, Krishnan S, Bashyum S, Knapp S, Guy RK. Floyd DM, et al. Among authors: clark ja. J Med Chem. 2016 Sep 8;59(17):7950-62. doi: 10.1021/acs.jmedchem.6b00752. Epub 2016 Aug 25. J Med Chem. 2016. PMID: 27505686 Free PMC article.
Evaluation of Diarylureas for Activity Against Plasmodium falciparum.
Zhang Y, Anderson M, Weisman JL, Lu M, Choy CJ, Boyd VA, Price J, Sigal M, Clark J, Connelly M, Zhu F, Guiguemde WA, Jeffries C, Yang L, Lemoff A, Liou AP, Webb TR, Derisi JL, Guy RK. Zhang Y, et al. Among authors: clark j. ACS Med Chem Lett. 2010 Dec 9;1(9):460-465. doi: 10.1021/ml100083c. ACS Med Chem Lett. 2010. PMID: 21243104 Free PMC article.
9,406 results