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Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics.
Zamboni V, Armentano M, Berto G, Ciraolo E, Ghigo A, Garzotto D, Umbach A, DiCunto F, Parmigiani E, Boido M, Vercelli A, El-Assawy N, Mauro A, Priano L, Ponzoni L, Murru L, Passafaro M, Hirsch E, Merlo GR. Zamboni V, et al. Among authors: ciraolo e. Sci Rep. 2018 May 8;8(1):7254. doi: 10.1038/s41598-018-25354-3. Sci Rep. 2018. PMID: 29740022 Free PMC article.
Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.
Zamboni V, Armentano M, Sarò G, Ciraolo E, Ghigo A, Germena G, Umbach A, Valnegri P, Passafaro M, Carabelli V, Gavello D, Bianchi V, D'Adamo P, de Curtis I, El-Assawi N, Mauro A, Priano L, Ferri N, Hirsch E, Merlo GR. Zamboni V, et al. Among authors: ciraolo e. Sci Rep. 2016 Oct 7;6:34877. doi: 10.1038/srep34877. Sci Rep. 2016. PMID: 27713499 Free PMC article.
Crossroads of PI3K and Rac pathways.
Campa CC, Ciraolo E, Ghigo A, Germena G, Hirsch E. Campa CC, et al. Among authors: ciraolo e. Small GTPases. 2015;6(2):71-80. doi: 10.4161/21541248.2014.989789. Epub 2015 May 5. Small GTPases. 2015. PMID: 25942647 Free PMC article. Review.
Taming the PI3K team to hold inflammation and cancer at bay.
Hirsch E, Ciraolo E, Ghigo A, Costa C. Hirsch E, et al. Among authors: ciraolo e. Pharmacol Ther. 2008 May;118(2):192-205. doi: 10.1016/j.pharmthera.2008.02.004. Epub 2008 Mar 5. Pharmacol Ther. 2008. PMID: 18420279 Review.
Measuring PI3K lipid kinase activity.
Ciraolo E, Perino A, Hirsch E. Ciraolo E, et al. Methods Mol Biol. 2012;795:55-67. doi: 10.1007/978-1-61779-337-0_4. Methods Mol Biol. 2012. PMID: 21960215
Rac signal adaptation controls neutrophil mobilization from the bone marrow.
Campa CC, Germena G, Ciraolo E, Copperi F, Sapienza A, Franco I, Ghigo A, Camporeale A, Di Savino A, Martini M, Perino A, Megens RT, Kurz AR, Scheiermann C, Sperandio M, Gamba A, Hirsch E. Campa CC, et al. Among authors: ciraolo e. Sci Signal. 2016 Dec 20;9(459):ra124. doi: 10.1126/scisignal.aah5882. Sci Signal. 2016. PMID: 27999173
Targeting PI3K in Cancer: Any Good News?
Martini M, Ciraolo E, Gulluni F, Hirsch E. Martini M, et al. Among authors: ciraolo e. Front Oncol. 2013 May 8;3:108. doi: 10.3389/fonc.2013.00108. eCollection 2013. Front Oncol. 2013. PMID: 23658859 Free PMC article.
35 results