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Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
Picco G, Cattaneo CM, van Vliet EJ, Crisafulli G, Rospo G, Consonni S, Vieira SF, Rodríguez IS, Cancelliere C, Banerjee R, Schipper LJ, Oddo D, Dijkstra KK, Cinatl J, Michaelis M, Yang F, Di Nicolantonio F, Sartore-Bianchi A, Siena S, Arena S, Voest EE, Bardelli A, Garnett MJ; Cell Model Network UK Group. Picco G, et al. Among authors: cinatl j. Cancer Discov. 2021 Aug;11(8):1923-1937. doi: 10.1158/2159-8290.CD-20-1508. Epub 2021 Apr 9. Cancer Discov. 2021. PMID: 33837064 Free article.
Valproic acid as anti-cancer drug.
Michaelis M, Doerr HW, Cinatl J Jr. Michaelis M, et al. Among authors: cinatl j jr. Curr Pharm Des. 2007;13(33):3378-93. Curr Pharm Des. 2007. PMID: 18045192 Review.
Resistance acquisition to MDM2 inhibitors.
Cinatl J, Speidel D, Hardcastle I, Michaelis M. Cinatl J, et al. Biochem Soc Trans. 2014 Aug;42(4):752-7. doi: 10.1042/BST20140035. Biochem Soc Trans. 2014. PMID: 25109953 Review.
The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis.
Kollareddy M, Sherrard A, Park JH, Szemes M, Gallacher K, Melegh Z, Oltean S, Michaelis M, Cinatl J Jr, Kaidi A, Malik K. Kollareddy M, et al. Among authors: cinatl j jr. Cancer Lett. 2017 Sep 10;403:74-85. doi: 10.1016/j.canlet.2017.05.027. Epub 2017 Jun 7. Cancer Lett. 2017. PMID: 28602975 Free PMC article.
461 results