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Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors.
ChemMedChem. 2019 Jan 8;14(1):169-181. doi: 10.1002/cmdc.201800569. Epub 2018 Dec 6.
ChemMedChem. 2019.
PMID: 30378281
Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.
Boutard N, Białas A, Sabiniarz A, Guzik P, Banaszak K, Biela A, Bień M, Buda A, Bugaj B, Cieluch E, Cierpich A, Dudek Ł, Eggenweiler HM, Fogt J, Gaik M, Gondela A, Jakubiec K, Jurzak M, Kitlińska A, Kowalczyk P, Kujawa M, Kwiecińska K, Leś M, Lindemann R, Maciuszek M, Mikulski M, Niedziejko P, Obara A, Pawlik H, Rzymski T, Sieprawska-Lupa M, Sowińska M, Szeremeta-Spisak J, Stachowicz A, Tomczyk MM, Wiklik K, Włoszczak Ł, Ziemiańska S, Zarębski A, Brzózka K, Nowak M, Fabritius CH.
Boutard N, et al. Among authors: cieluch e.
Bioorg Med Chem Lett. 2019 Feb 15;29(4):646-653. doi: 10.1016/j.bmcl.2018.12.034. Epub 2018 Dec 16.
Bioorg Med Chem Lett. 2019.
PMID: 30626557
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Discrimination between two possible reaction sequences that create potential risk of generation of deleterious radicals by cytochrome bc₁. Implications for the mechanism of superoxide production.
Sarewicz M, Borek A, Cieluch E, Swierczek M, Osyczka A.
Sarewicz M, et al. Among authors: cieluch e.
Biochim Biophys Acta. 2010 Nov;1797(11):1820-7. doi: 10.1016/j.bbabio.2010.07.005. Epub 2010 Jul 15.
Biochim Biophys Acta. 2010.
PMID: 20637719
Free PMC article.
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Catalytically-relevant electron transfer between two hemes bL in the hybrid cytochrome bc1-like complex containing a fusion of Rhodobacter sphaeroides and capsulatus cytochromes b.
Czapla M, Cieluch E, Borek A, Sarewicz M, Osyczka A.
Czapla M, et al. Among authors: cieluch e.
Biochim Biophys Acta. 2013 Jun;1827(6):751-60. doi: 10.1016/j.bbabio.2013.02.007. Epub 2013 Feb 18.
Biochim Biophys Acta. 2013.
PMID: 23428397
Free PMC article.
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Visualizing changes in electron distribution in coupled chains of cytochrome bc(1) by modifying barrier for electron transfer between the FeS cluster and heme c(1).
Cieluch E, Pietryga K, Sarewicz M, Osyczka A.
Cieluch E, et al.
Biochim Biophys Acta. 2010 Feb;1797(2):296-303. doi: 10.1016/j.bbabio.2009.11.003. Epub 2009 Nov 14.
Biochim Biophys Acta. 2010.
PMID: 19917265
Free PMC article.
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An electronic bus bar lies in the core of cytochrome bc1.
Swierczek M, Cieluch E, Sarewicz M, Borek A, Moser CC, Dutton PL, Osyczka A.
Swierczek M, et al. Among authors: cieluch e.
Science. 2010 Jul 23;329(5990):451-4. doi: 10.1126/science.1190899.
Science. 2010.
PMID: 20651150
Free PMC article.
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Tuning of Hemes b Equilibrium Redox Potential Is Not Required for Cross-Membrane Electron Transfer.
Pintscher S, Kuleta P, Cieluch E, Borek A, Sarewicz M, Osyczka A.
Pintscher S, et al. Among authors: cieluch e.
J Biol Chem. 2016 Mar 25;291(13):6872-81. doi: 10.1074/jbc.M115.712307. Epub 2016 Feb 8.
J Biol Chem. 2016.
PMID: 26858251
Free PMC article.
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