Chu K - Search Results

1

Promoterless gene targeting without nucleases ameliorates haemophilia B in mice.

Barzel A, Paulk NK, Shi Y, Huang Y, Chu K, Zhang F, Valdmanis PN, Spector LP, Porteus MH, Gaensler KM, Kay MA. Barzel A, et al. Among authors: chu k. Nature. 2015 Jan 15;517(7534):360-4. doi: 10.1038/nature13864. Epub 2014 Oct 29. Nature. 2015. PMID: 25363772 Free PMC article.

2

RNA interference-induced hepatotoxicity results from loss of the first synthesized isoform of microRNA-122 in mice.

Valdmanis PN, Gu S, Chu K, Jin L, Zhang F, Munding EM, Zhang Y, Huang Y, Kutay H, Ghoshal K, Lisowski L, Kay MA. Valdmanis PN, et al. Among authors: chu k. Nat Med. 2016 May;22(5):557-62. doi: 10.1038/nm.4079. Epub 2016 Apr 11. Nat Med. 2016. PMID: 27064447 Free PMC article.

3

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model.

Lisowski L, Dane AP, Chu K, Zhang Y, Cunningham SC, Wilson EM, Nygaard S, Grompe M, Alexander IE, Kay MA. Lisowski L, et al. Among authors: chu k. Nature. 2014 Feb 20;506(7488):382-6. doi: 10.1038/nature12875. Epub 2013 Dec 25. Nature. 2014. PMID: 24390344 Free PMC article.

4

A 5' Noncoding Exon Containing Engineered Intron Enhances Transgene Expression from Recombinant AAV Vectors in vivo.

Lu J, Williams JA, Luke J, Zhang F, Chu K, Kay MA. Lu J, et al. Among authors: chu k. Hum Gene Ther. 2017 Jan;28(1):125-134. doi: 10.1089/hum.2016.140. Hum Gene Ther. 2017. PMID: 27903072 Free PMC article.

5

miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression.

Valdmanis PN, Kim HK, Chu K, Zhang F, Xu J, Munding EM, Shen J, Kay MA. Valdmanis PN, et al. Among authors: chu k. Nat Commun. 2018 Dec 14;9(1):5321. doi: 10.1038/s41467-018-07786-7. Nat Commun. 2018. PMID: 30552326 Free PMC article.

6

Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity.

Paulk NK, Pekrun K, Zhu E, Nygaard S, Li B, Xu J, Chu K, Leborgne C, Dane AP, Haft A, Zhang Y, Zhang F, Morton C, Valentine MB, Davidoff AM, Nathwani AC, Mingozzi F, Grompe M, Alexander IE, Lisowski L, Kay MA. Paulk NK, et al. Among authors: chu k. Mol Ther. 2018 Jan 3;26(1):289-303. doi: 10.1016/j.ymthe.2017.09.021. Epub 2017 Sep 25. Mol Ther. 2018. PMID: 29055620 Free PMC article.

7

A transfer-RNA-derived small RNA regulates ribosome biogenesis.

Kim HK, Fuchs G, Wang S, Wei W, Zhang Y, Park H, Roy-Chaudhuri B, Li P, Xu J, Chu K, Zhang F, Chua MS, So S, Zhang QC, Sarnow P, Kay MA. Kim HK, et al. Among authors: chu k. Nature. 2017 Dec 7;552(7683):57-62. doi: 10.1038/nature25005. Epub 2017 Nov 29. Nature. 2017. PMID: 29186115 Free PMC article.

8

Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma.

Valdmanis PN, Roy-Chaudhuri B, Kim HK, Sayles LC, Zheng Y, Chuang CH, Caswell DR, Chu K, Zhang Y, Winslow MM, Sweet-Cordero EA, Kay MA. Valdmanis PN, et al. Among authors: chu k. Oncogene. 2015 Jan 2;34(1):94-103. doi: 10.1038/onc.2013.523. Epub 2013 Dec 9. Oncogene. 2015. PMID: 24317514 Free PMC article.

9

The anti-genomic (negative) strand of Hepatitis C Virus is not targetable by shRNA.

Lisowski L, Elazar M, Chu K, Glenn JS, Kay MA. Lisowski L, et al. Among authors: chu k. Nucleic Acids Res. 2013 Apr 1;41(6):3688-98. doi: 10.1093/nar/gkt068. Epub 2013 Feb 8. Nucleic Acids Res. 2013. PMID: 23396439 Free PMC article.

10

A tRNA-Derived Small RNA Regulates Ribosomal Protein S28 Protein Levels after Translation Initiation in Humans and Mice.

Kim HK, Xu J, Chu K, Park H, Jang H, Li P, Valdmanis PN, Zhang QC, Kay MA. Kim HK, et al. Among authors: chu k. Cell Rep. 2019 Dec 17;29(12):3816-3824.e4. doi: 10.1016/j.celrep.2019.11.062. Cell Rep. 2019. PMID: 31851915 Free PMC article.

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