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Unconventional insulins from predators and pathogens.
Laugesen SH, Chou DH, Safavi-Hemami H. Laugesen SH, et al. Among authors: chou dh. Nat Chem Biol. 2022 Jul;18(7):688-697. doi: 10.1038/s41589-022-01068-6. Epub 2022 Jun 27. Nat Chem Biol. 2022. PMID: 35761080 Review.
A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.
Menting JG, Gajewiak J, MacRaild CA, Chou DH, Disotuar MM, Smith NA, Miller C, Erchegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H, Lawrence MC. Menting JG, et al. Among authors: chou dh. Nat Struct Mol Biol. 2016 Oct;23(10):916-920. doi: 10.1038/nsmb.3292. Epub 2016 Sep 12. Nat Struct Mol Biol. 2016. PMID: 27617429
A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Xiong X, Menting JG, Disotuar MM, Smith NA, Delaine CA, Ghabash G, Agrawal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, Safavi-Hemami H, Olivera B, Lawrence MC, Chou DH. Xiong X, et al. Among authors: chou dh. Nat Struct Mol Biol. 2020 Jul;27(7):615-624. doi: 10.1038/s41594-020-0430-8. Epub 2020 Jun 1. Nat Struct Mol Biol. 2020. PMID: 32483339 Free PMC article.
Author Correction: A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Xiong X, Menting JG, Disotuar MM, Smith NA, Delaine CA, Ghabash G, Agrawal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, Safavi-Hemami H, Olivera B, Lawrence MC, Chou DH. Xiong X, et al. Among authors: chou dh. Nat Struct Mol Biol. 2020 Jul;27(7):683. doi: 10.1038/s41594-020-0460-2. Nat Struct Mol Biol. 2020. PMID: 32533129
Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Xiong X, Blakely A, Kim JH, Menting JG, Schäfer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun Ü, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH. Xiong X, et al. Among authors: chou dh. Nat Chem Biol. 2022 May;18(5):511-519. doi: 10.1038/s41589-022-00981-0. Epub 2022 Mar 14. Nat Chem Biol. 2022. PMID: 35289328 Free PMC article.
Novel four-disulfide insulin analog with high aggregation stability and potency.
Xiong X, Blakely A, Karra P, VandenBerg MA, Ghabash G, Whitby F, Zhang YW, Webber MJ, Holland WL, Hill CP, Chou DH. Xiong X, et al. Among authors: chou dh. Chem Sci. 2019 Nov 5;11(1):195-200. doi: 10.1039/c9sc04555d. eCollection 2020 Jan 7. Chem Sci. 2019. PMID: 32110371 Free PMC article.
38 results