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Genotype-free demultiplexing of pooled single-cell RNA-seq.
Xu J, Falconer C, Nguyen Q, Crawford J, McKinnon BD, Mortlock S, Senabouth A, Andersen S, Chiu HS, Jiang L, Palpant NJ, Yang J, Mueller MD, Hewitt AW, Pébay A, Montgomery GW, Powell JE, Coin LJM. Xu J, et al. Among authors: chiu hs. Genome Biol. 2019 Dec 19;20(1):290. doi: 10.1186/s13059-019-1852-7. Genome Biol. 2019. PMID: 31856883 Free PMC article.
Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species.
Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF. Muttenthaler M, et al. Among authors: chiu hs. Sci Signal. 2017 Dec 5;10(508):eaan3398. doi: 10.1126/scisignal.aan3398. Sci Signal. 2017. PMID: 29208680 Free PMC article.
Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation.
Friedman CE, Nguyen Q, Lukowski SW, Helfer A, Chiu HS, Miklas J, Levy S, Suo S, Han JJ, Osteil P, Peng G, Jing N, Baillie GJ, Senabouth A, Christ AN, Bruxner TJ, Murry CE, Wong ES, Ding J, Wang Y, Hudson J, Ruohola-Baker H, Bar-Joseph Z, Tam PPL, Powell JE, Palpant NJ. Friedman CE, et al. Among authors: chiu hs. Cell Stem Cell. 2018 Oct 4;23(4):586-598.e8. doi: 10.1016/j.stem.2018.09.009. Cell Stem Cell. 2018. PMID: 30290179 Free PMC article.
Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells.
Neavin D, Nguyen Q, Daniszewski MS, Liang HH, Chiu HS, Wee YK, Senabouth A, Lukowski SW, Crombie DE, Lidgerwood GE, Hernández D, Vickers JC, Cook AL, Palpant NJ, Pébay A, Hewitt AW, Powell JE. Neavin D, et al. Among authors: chiu hs. Genome Biol. 2021 Mar 5;22(1):76. doi: 10.1186/s13059-021-02293-3. Genome Biol. 2021. PMID: 33673841 Free PMC article.
Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury.
Redd MA, Scheuer SE, Saez NJ, Yoshikawa Y, Chiu HS, Gao L, Hicks M, Villanueva JE, Joshi Y, Chow CY, Cuellar-Partida G, Peart JN, See Hoe LE, Chen X, Sun Y, Suen JY, Hatch RJ, Rollo B, Xia D, Alzubaidi MAH, Maljevic S, Quaife-Ryan GA, Hudson JE, Porrello ER, White MY, Cordwell SJ, Fraser JF, Petrou S, Reichelt ME, Thomas WG, King GF, Macdonald PS, Palpant NJ. Redd MA, et al. Among authors: chiu hs. Circulation. 2021 Sep 21;144(12):947-960. doi: 10.1161/CIRCULATIONAHA.121.054360. Epub 2021 Jul 15. Circulation. 2021. PMID: 34264749 Free article.
A village in a dish model system for population-scale hiPSC studies.
Neavin DR, Steinmann AM, Farbehi N, Chiu HS, Daniszewski MS, Arora H, Bermudez Y, Moutinho C, Chan CL, Bax M, Tyebally M, Gnanasambandapillai V, Lam CE, Nguyen U, Hernández D, Lidgerwood GE, Graham RM, Hewitt AW, Pébay A, Palpant NJ, Powell JE. Neavin DR, et al. Among authors: chiu hs. Nat Commun. 2023 Jun 9;14(1):3240. doi: 10.1038/s41467-023-38704-1. Nat Commun. 2023. PMID: 37296104 Free PMC article.
HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function.
Friedman CE, Cheetham SW, Negi S, Mills RJ, Ogawa M, Redd MA, Chiu HS, Shen S, Sun Y, Mizikovsky D, Bouveret R, Chen X, Voges HK, Paterson S, De Angelis JE, Andersen SB, Cao Y, Wu Y, Jafrani YMA, Yoon S, Faulkner GJ, Smith KA, Porrello E, Harvey RP, Hogan BM, Nguyen Q, Zeng J, Kikuchi K, Hudson JE, Palpant NJ. Friedman CE, et al. Among authors: chiu hs. Dev Cell. 2024 Jan 8;59(1):91-107.e6. doi: 10.1016/j.devcel.2023.11.012. Epub 2023 Dec 12. Dev Cell. 2024. PMID: 38091997
Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney.
Georgas K, Rumballe B, Wilkinson L, Chiu HS, Lesieur E, Gilbert T, Little MH. Georgas K, et al. Among authors: chiu hs. Histochem Cell Biol. 2008 Nov;130(5):927-42. doi: 10.1007/s00418-008-0454-3. Epub 2008 Jul 11. Histochem Cell Biol. 2008. PMID: 18618131
67 results