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TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma.
Ennishi D, Healy S, Bashashati A, Saberi S, Hother C, Mottok A, Chan FC, Chong L, Abraham L, Kridel R, Boyle M, Meissner B, Aoki T, Takata K, Woolcock BW, Viganò E, Gold M, Molday LL, Molday RS, Telenius A, Li MY, Wretham N, Dos Santos N, Wong M, Viller NN, Uger RA, Duns G, Baticados A, Madero A, Bristow BN, Farinha P, Slack GW, Ben-Neriah S, Lai D, Zhang AW, Salehi S, Shulha HP, Chiu DS, Mostafavi S, Gerrie AS, Huang DW, Rushton C, Villa D, Sehn LH, Savage KJ, Mungall AJ, Weng AP, Bally MB, Morin RD, Cohen Freue GV, Staudt LM, Connors JM, Marra MA, Shah SP, Gascoyne RD, Scott DW, Steidl C. Ennishi D, et al. Among authors: chiu ds. Nat Med. 2020 Apr;26(4):577-588. doi: 10.1038/s41591-020-0757-z. Epub 2020 Feb 24. Nat Med. 2020. PMID: 32094924 Free PMC article.
Single-Patient Molecular Testing with NanoString nCounter Data Using a Reference-Based Strategy for Batch Effect Correction.
Talhouk A, Kommoss S, Mackenzie R, Cheung M, Leung S, Chiu DS, Kalloger SE, Huntsman DG, Chen S, Intermaggio M, Gronwald J, Chan FC, Ramus SJ, Steidl C, Scott DW, Anglesio MS. Talhouk A, et al. Among authors: chiu ds. PLoS One. 2016 Apr 20;11(4):e0153844. doi: 10.1371/journal.pone.0153844. eCollection 2016. PLoS One. 2016. PMID: 27096160 Free PMC article.
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S. Xu H, et al. Among authors: chiu ds. Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432. Nat Commun. 2017. PMID: 28211448 Free PMC article.
Synthesis of diagnostic quality cancer pathology images by generative adversarial networks.
Levine AB, Peng J, Farnell D, Nursey M, Wang Y, Naso JR, Ren H, Farahani H, Chen C, Chiu D, Talhouk A, Sheffield B, Riazy M, Ip PP, Parra-Herran C, Mills A, Singh N, Tessier-Cloutier B, Salisbury T, Lee J, Salcudean T, Jones SJ, Huntsman DG, Gilks CB, Yip S, Bashashati A. Levine AB, et al. J Pathol. 2020 Oct;252(2):178-188. doi: 10.1002/path.5509. Epub 2020 Sep 8. J Pathol. 2020. PMID: 32686118
Oncogenic mutations in histologically normal endometrium: the new normal?
Lac V, Nazeran TM, Tessier-Cloutier B, Aguirre-Hernandez R, Albert A, Lum A, Khattra J, Praetorius T, Mason M, Chiu D, Köbel M, Yong PJ, Gilks BC, Anglesio MS, Huntsman DG. Lac V, et al. J Pathol. 2019 Oct;249(2):173-181. doi: 10.1002/path.5314. Epub 2019 Jul 22. J Pathol. 2019. PMID: 31187483
Hormone receptor expression and outcomes in low-grade serous ovarian carcinoma.
Llaurado Fernandez M, Dawson A, Kim H, Lam N, Russell H, Bruce M, Bittner M, Hoenisch J, Scott SA, Talhouk A, Chiu D, Provencher D, Nourmoussavi M, DiMattia G, Lee CH, Gilks CB, Köbel M, Carey MS. Llaurado Fernandez M, et al. Gynecol Oncol. 2020 Apr;157(1):12-20. doi: 10.1016/j.ygyno.2019.11.029. Epub 2020 Jan 15. Gynecol Oncol. 2020. PMID: 31954537
Endometrial Cancer Molecular Risk Stratification is Equally Prognostic for Endometrioid Ovarian Carcinoma.
Krämer P, Talhouk A, Brett MA, Chiu DS, Cairns ES, Scheunhage DA, Hammond RFL, Farnell D, Nazeran TM, Grube M, Xia Z, Senz J, Leung S, Feil L, Pasternak J, Dixon K, Hartkopf A, Krämer B, Brucker S, Heitz F, du Bois A, Harter P, Kommoss FKF, Sinn HP, Heublein S, Kommoss F, Vollert HW, Manchanda R, de Kroon CD, Nijman HW, de Bruyn M, Thompson EF, Bashashati A, McAlpine JN, Singh N, Tinker AV, Staebler A, Bosse T, Kommoss S, Köbel M, Anglesio MS. Krämer P, et al. Among authors: chiu ds. Clin Cancer Res. 2020 Oct 15;26(20):5400-5410. doi: 10.1158/1078-0432.CCR-20-1268. Epub 2020 Jul 31. Clin Cancer Res. 2020. PMID: 32737030
Evaluation of treatment effects in patients with endometrial cancer and POLE mutations: An individual patient data meta-analysis.
McAlpine JN, Chiu DS, Nout RA, Church DN, Schmidt P, Lam S, Leung S, Bellone S, Wong A, Brucker SY, Lee CH, Clarke BA, Huntsman DG, Bernardini MQ, Ngeow J, Santin AD, Goodfellow P, Levine DA, Köbel M, Kommoss S, Bosse T, Gilks CB, Talhouk A. McAlpine JN, et al. Among authors: chiu ds. Cancer. 2021 Jul 15;127(14):2409-2422. doi: 10.1002/cncr.33516. Epub 2021 Apr 1. Cancer. 2021. PMID: 33793971 Free article.
40 results