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Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population.
Wang HL, Yeh TH, Huang YZ, Weng YH, Chen RS, Lu CS, Wei KC, Liu YC, Chen YL, Chen CL, Chen YJ, Lin YW, Hsu CC, Chiu CH, Chiu CC. Wang HL, et al. Among authors: chiu cc, chiu ch. Neurobiol Aging. 2021 Nov;107:189-196. doi: 10.1016/j.neurobiolaging.2021.06.011. Epub 2021 Jun 19. Neurobiol Aging. 2021. PMID: 34275689
PARK14 PLA2G6 mutants are defective in preventing rotenone-induced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway.
Chiu CC, Yeh TH, Lu CS, Huang YC, Cheng YC, Huang YZ, Weng YH, Liu YC, Lai SC, Chen YL, Chen YJ, Chen CL, Chen HY, Lin YW, Wang HL. Chiu CC, et al. Oncotarget. 2017 Sep 15;8(45):79046-79060. doi: 10.18632/oncotarget.20893. eCollection 2017 Oct 3. Oncotarget. 2017. PMID: 29108286 Free PMC article.
PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model.
Chiu CC, Lu CS, Weng YH, Chen YL, Huang YZ, Chen RS, Cheng YC, Huang YC, Liu YC, Lai SC, Lin KJ, Lin YW, Chen YJ, Chen CL, Yeh TH, Wang HL. Chiu CC, et al. Mol Neurobiol. 2019 Jun;56(6):3835-3853. doi: 10.1007/s12035-018-1118-5. Epub 2018 Aug 8. Mol Neurobiol. 2019. PMID: 30088174
921 results