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Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults.
Killingley B, Mann AJ, Kalinova M, Boyers A, Goonawardane N, Zhou J, Lindsell K, Hare SS, Brown J, Frise R, Smith E, Hopkins C, Noulin N, Löndt B, Wilkinson T, Harden S, McShane H, Baillet M, Gilbert A, Jacobs M, Charman C, Mande P, Nguyen-Van-Tam JS, Semple MG, Read RC, Ferguson NM, Openshaw PJ, Rapeport G, Barclay WS, Catchpole AP, Chiu C. Killingley B, et al. Among authors: chiu c. Nat Med. 2022 May;28(5):1031-1041. doi: 10.1038/s41591-022-01780-9. Epub 2022 Mar 31. Nat Med. 2022. PMID: 35361992 Clinical Trial.
Protective and dysregulated T cell immunity in RSV infection.
Openshaw PJ, Chiu C. Openshaw PJ, et al. Among authors: chiu c. Curr Opin Virol. 2013 Aug;3(4):468-74. doi: 10.1016/j.coviro.2013.05.005. Epub 2013 Jun 25. Curr Opin Virol. 2013. PMID: 23806514 Free PMC article. Review.
Current concepts and progress in RSV vaccine development.
Guvenel AK, Chiu C, Openshaw PJ. Guvenel AK, et al. Among authors: chiu c. Expert Rev Vaccines. 2014 Mar;13(3):333-44. doi: 10.1586/14760584.2014.878653. Epub 2014 Jan 9. Expert Rev Vaccines. 2014. PMID: 24405366 Free PMC article. Review.
Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus.
Habibi MS, Jozwik A, Makris S, Dunning J, Paras A, DeVincenzo JP, de Haan CA, Wrammert J, Openshaw PJ, Chiu C; Mechanisms of Severe Acute Influenza Consortium Investigators. Habibi MS, et al. Among authors: chiu c. Am J Respir Crit Care Med. 2015 May 1;191(9):1040-9. doi: 10.1164/rccm.201412-2256OC. Am J Respir Crit Care Med. 2015. PMID: 25730467 Free PMC article. Clinical Trial.
RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection.
Jozwik A, Habibi MS, Paras A, Zhu J, Guvenel A, Dhariwal J, Almond M, Wong EHC, Sykes A, Maybeno M, Del Rosario J, Trujillo-Torralbo MB, Mallia P, Sidney J, Peters B, Kon OM, Sette A, Johnston SL, Openshaw PJ, Chiu C. Jozwik A, et al. Among authors: chiu c. Nat Commun. 2015 Dec 21;6:10224. doi: 10.1038/ncomms10224. Nat Commun. 2015. PMID: 26687547 Free PMC article.
Protective and Harmful Immunity to RSV Infection.
Openshaw PJM, Chiu C, Culley FJ, Johansson C. Openshaw PJM, et al. Among authors: chiu c. Annu Rev Immunol. 2017 Apr 26;35:501-532. doi: 10.1146/annurev-immunol-051116-052206. Epub 2017 Feb 6. Annu Rev Immunol. 2017. PMID: 28226227 Review.
Local and Systemic Immunity against Respiratory Syncytial Virus Induced by a Novel Intranasal Vaccine. A Randomized, Double-Blind, Placebo-controlled Clinical Trial.
Ascough S, Vlachantoni I, Kalyan M, Haijema BJ, Wallin-Weber S, Dijkstra-Tiekstra M, Ahmed MS, van Roosmalen M, Grimaldi R, Zhang Q, Leenhouts K, Openshaw PJ, Chiu C. Ascough S, et al. Among authors: chiu c. Am J Respir Crit Care Med. 2019 Aug 15;200(4):481-492. doi: 10.1164/rccm.201810-1921OC. Am J Respir Crit Care Med. 2019. PMID: 30753101 Free PMC article. Clinical Trial.
Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection.
Habibi MS, Thwaites RS, Chang M, Jozwik A, Paras A, Kirsebom F, Varese A, Owen A, Cuthbertson L, James P, Tunstall T, Nickle D, Hansel TT, Moffatt MF, Johansson C, Chiu C, Openshaw PJM. Habibi MS, et al. Among authors: chiu c. Science. 2020 Oct 9;370(6513):eaba9301. doi: 10.1126/science.aba9301. Science. 2020. PMID: 33033192 Free PMC article.
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.
Thwaites RS, Sanchez Sevilla Uruchurtu A, Siggins MK, Liew F, Russell CD, Moore SC, Fairfield C, Carter E, Abrams S, Short CE, Thaventhiran T, Bergstrom E, Gardener Z, Ascough S, Chiu C, Docherty AB, Hunt D, Crow YJ, Solomon T, Taylor GP, Turtle L, Harrison EM, Dunning J, Semple MG, Baillie JK, Openshaw PJ; ISARIC4C investigators. Thwaites RS, et al. Among authors: chiu c. Sci Immunol. 2021 Mar 10;6(57):eabg9873. doi: 10.1126/sciimmunol.abg9873. Sci Immunol. 2021. PMID: 33692097 Free PMC article.
5,444 results