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Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.
Chassagnon IR, McCarthy CA, Chin YK, Pineda SS, Keramidas A, Mobli M, Pham V, De Silva TM, Lynch JW, Widdop RE, Rash LD, King GF. Chassagnon IR, et al. Among authors: chin yk. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3750-3755. doi: 10.1073/pnas.1614728114. Epub 2017 Mar 20. Proc Natl Acad Sci U S A. 2017. PMID: 28320941 Free PMC article.
The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.
Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, Rash LD. Wingerd JS, et al. Among authors: chin yk. Sci Rep. 2017 Apr 20;7(1):974. doi: 10.1038/s41598-017-01129-0. Sci Rep. 2017. PMID: 28428547 Free PMC article.
A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals.
Eagles DA, Saez NJ, Krishnarjuna B, Bradford JJ, Chin YK, Starobova H, Mueller A, Reichelt ME, Undheim EAB, Norton RS, Thomas WG, Vetter I, King GF, Robinson SD. Eagles DA, et al. Among authors: chin yk. Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):e2112630119. doi: 10.1073/pnas.2112630119. Proc Natl Acad Sci U S A. 2022. PMID: 35131940 Free PMC article.
47 results