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PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models.
Pignochino Y, Capozzi F, D'Ambrosio L, Dell'Aglio C, Basiricò M, Canta M, Lorenzato A, Vignolo Lutati F, Aliberti S, Palesandro E, Boccone P, Galizia D, Miano S, Chiabotto G, Napione L, Gammaitoni L, Sangiolo D, Benassi MS, Pasini B, Chiorino G, Aglietta M, Grignani G. Pignochino Y, et al. Among authors: chiabotto g. Mol Cancer. 2017 Apr 28;16(1):86. doi: 10.1186/s12943-017-0652-5. Mol Cancer. 2017. PMID: 28454547 Free PMC article.
Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group.
Grignani G, D'Ambrosio L, Pignochino Y, Palmerini E, Zucchetti M, Boccone P, Aliberti S, Stacchiotti S, Bertulli R, Piana R, Miano S, Tolomeo F, Chiabotto G, Sangiolo D, Pisacane A, Dei Tos AP, Novara L, Bartolini A, Marchesi E, D'Incalci M, Bardelli A, Picci P, Ferrari S, Aglietta M. Grignani G, et al. Among authors: chiabotto g. Lancet Oncol. 2018 Oct;19(10):1360-1371. doi: 10.1016/S1470-2045(18)30438-8. Epub 2018 Sep 11. Lancet Oncol. 2018. PMID: 30217671 Free article. Clinical Trial.
Pazopanib and Trametinib as a Synergistic Strategy against Osteosarcoma: Preclinical Activity and Molecular Insights.
Chiabotto G, Grignani G, Todorovic M, Martin V, Centomo ML, Prola E, Giordano G, Merlini A, Miglio U, Berrino E, Napione L, Isella C, Capozzi F, Basiricò M, Marsero C, Gerardi I, Venesio T, Sangiolo D, Aglietta M, D'Ambrosio L, Pignochino Y. Chiabotto G, et al. Cancers (Basel). 2020 Jun 10;12(6):1519. doi: 10.3390/cancers12061519. Cancers (Basel). 2020. PMID: 32531992 Free PMC article.
PARP1 Inhibitor and Trabectedin Combination Does Not Increase Tumor Mutational Burden in Advanced Sarcomas-A Preclinical and Translational Study.
Pignochino Y, Crisafulli G, Giordano G, Merlini A, Berrino E, Centomo ML, Chiabotto G, Brusco S, Basiricò M, Maldi E, Pisacane A, Leuci V, Sangiolo D, D'Ambrosio L, Aglietta M, Kasper B, Bardelli A, Grignani G. Pignochino Y, et al. Among authors: chiabotto g. Cancers (Basel). 2021 Dec 15;13(24):6295. doi: 10.3390/cancers13246295. Cancers (Basel). 2021. PMID: 34944915 Free PMC article.
DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination.
Merlini A, Centomo ML, Ferrero G, Chiabotto G, Miglio U, Berrino E, Giordano G, Brusco S, Pisacane A, Maldi E, Sarotto I, Capozzi F, Lano C, Isella C, Crisafulli G, Aglietta M, Dei Tos AP, Sbaraglia M, Sangiolo D, D'Ambrosio L, Bardelli A, Pignochino Y, Grignani G. Merlini A, et al. Among authors: chiabotto g. Front Oncol. 2022 Aug 30;12:844250. doi: 10.3389/fonc.2022.844250. eCollection 2022. Front Oncol. 2022. PMID: 36110934 Free PMC article.
Role of extracellular vesicles in stem cell biology.
Bruno S, Chiabotto G, Favaro E, Deregibus MC, Camussi G. Bruno S, et al. Among authors: chiabotto g. Am J Physiol Cell Physiol. 2019 Aug 1;317(2):C303-C313. doi: 10.1152/ajpcell.00129.2019. Epub 2019 May 15. Am J Physiol Cell Physiol. 2019. PMID: 31091143 Free PMC article. Review.
22 results