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Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies.
Si J, Shi X, Sun S, Zou B, Li Y, An D, Lin X, Gao Y, Long F, Pang B, Liu X, Liu T, Chi W, Chen L, Dimitrov DS, Sun Y, Du X, Yin W, Gao G, Min J, Wei L, Liao X. Si J, et al. Among authors: chi w. Cancer Cell. 2020 Oct 12;38(4):551-566.e11. doi: 10.1016/j.ccell.2020.08.001. Epub 2020 Aug 28. Cancer Cell. 2020. PMID: 32860752 Free article.
Ablation of Proton/Glucose Exporter SLC45A2 Enhances Melanosomal Glycolysis to Inhibit Melanin Biosynthesis and Promote Melanoma Metastasis.
Liu Y, Chi W, Tao L, Wang G, Deepak RNVK, Sheng L, Chen T, Feng Y, Cao X, Cheng L, Zhao X, Liu X, Deng H, Fan H, Jiang P, Chen L. Liu Y, et al. Among authors: chi w. J Invest Dermatol. 2022 Oct;142(10):2744-2755.e9. doi: 10.1016/j.jid.2022.04.008. Epub 2022 Apr 23. J Invest Dermatol. 2022. PMID: 35469906 Free article.
Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis.
Cheng L, Deepak RNVK, Wang G, Meng Z, Tao L, Xie M, Chi W, Zhang Y, Yang M, Liao Y, Chen R, Liang Y, Zhang J, Huang Y, Wang W, Guo Z, Wang Y, Lin JD, Fan H, Chen L. Cheng L, et al. Among authors: chi w. Hepatology. 2023 Dec 1;78(6):1828-1842. doi: 10.1097/HEP.0000000000000314. Epub 2023 Feb 22. Hepatology. 2023. PMID: 36804859 Free PMC article.
Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity.
Cheng L, Ge M, Lan Z, Ma Z, Chi W, Kuang W, Sun K, Zhao X, Liu Y, Feng Y, Huang Y, Luo M, Li L, Zhang B, Hu X, Xu L, Liu X, Huo Y, Deng H, Yang J, Xi Q, Zhang Y, Siegenthaler JA, Chen L. Cheng L, et al. Among authors: chi w. Arch Toxicol. 2018 Jan;92(1):469-485. doi: 10.1007/s00204-017-2048-0. Epub 2017 Sep 4. Arch Toxicol. 2018. PMID: 28871336 Free PMC article.
Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans.
Che L, Chi W, Qiao Y, Zhang J, Song X, Liu Y, Li L, Jia J, Pilo MG, Wang J, Cigliano A, Ma Z, Kuang W, Tang Z, Zhang Z, Shui G, Ribback S, Dombrowski F, Evert M, Pascale RM, Cossu C, Pes GM, Osborne TF, Calvisi DF, Chen X, Chen L. Che L, et al. Among authors: chi w. Gut. 2020 Jan;69(1):177-186. doi: 10.1136/gutjnl-2018-317581. Epub 2019 Apr 6. Gut. 2020. PMID: 30954949 Free PMC article.
787 results