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PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
Berlin M, Cantley J, Bookbinder M, Bortolon E, Broccatelli F, Cadelina G, Chan EW, Chen H, Chen X, Cheng Y, Cheung TK, Davenport K, DiNicola D, Gordon D, Hamman BD, Harbin A, Haskell R, He M, Hole AJ, Januario T, Kerry PS, Koenig SG, Li L, Merchant M, Pérez-Dorado I, Pizzano J, Quinn C, Rose CM, Rousseau E, Soto L, Staben LR, Sun H, Tian Q, Wang J, Wang W, Ye CS, Ye X, Zhang P, Zhou Y, Yauch R, Dragovich PS. Berlin M, et al. Among authors: cheung tk. J Med Chem. 2024 Jan 25;67(2):1262-1313. doi: 10.1021/acs.jmedchem.3c01781. Epub 2024 Jan 5. J Med Chem. 2024. PMID: 38180485
Dynamic Regulation of Mitochondrial Import by the Ubiquitin System.
Phu L, Rose CM, Tea JS, Wall CE, Verschueren E, Cheung TK, Kirkpatrick DS, Bingol B. Phu L, et al. Among authors: cheung tk. Mol Cell. 2020 Mar 5;77(5):1107-1123.e10. doi: 10.1016/j.molcel.2020.02.012. Mol Cell. 2020. PMID: 32142684 Free article.
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.
Cantley J, Ye X, Rousseau E, Januario T, Hamman BD, Rose CM, Cheung TK, Hinkle T, Soto L, Quinn C, Harbin A, Bortolon E, Chen X, Haskell R, Lin E, Yu SF, Del Rosario G, Chan E, Dunlap D, Koeppen H, Martin S, Merchant M, Grimmer M, Broccatelli F, Wang J, Pizzano J, Dragovich PS, Berlin M, Yauch RL. Cantley J, et al. Among authors: cheung tk. Nat Commun. 2022 Nov 10;13(1):6814. doi: 10.1038/s41467-022-34562-5. Nat Commun. 2022. PMID: 36357397 Free PMC article.
Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection.
Luchetti G, Roncaioli JL, Chavez RA, Schubert AF, Kofoed EM, Reja R, Cheung TK, Liang Y, Webster JD, Lehoux I, Skippington E, Reeder J, Haley B, Tan MW, Rose CM, Newton K, Kayagaki N, Vance RE, Dixit VM. Luchetti G, et al. Among authors: cheung tk. Cell Host Microbe. 2021 Oct 13;29(10):1521-1530.e10. doi: 10.1016/j.chom.2021.08.010. Epub 2021 Sep 6. Cell Host Microbe. 2021. PMID: 34492225 Free PMC article.
Context-specific stress causes compartmentalized SARM1 activation and local degeneration in cortical neurons.
Hinz FI, Villegas CLM, Roberts JT, Yao H, Gaddam S, Delwig A, Green SA, Fredrickson C, Adrian M, Asuncion RR, Cheung TK, Hayne M, Hackos DH, Rose CM, Richmond D, Hoogenraad CC. Hinz FI, et al. Among authors: cheung tk. J Neurosci. 2024 May 1:e2424232024. doi: 10.1523/JNEUROSCI.2424-23.2024. Online ahead of print. J Neurosci. 2024. PMID: 38692735
Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity.
Guidi R, Wedeles C, Xu D, Kolmus K, Headland SE, Teng G, Guillory J, Zeng YJ, Cheung TK, Chaudhuri S, Modrusan Z, Liang Y, Horswell S, Haley B, Rutz S, Rose C, Franke Y, Kirkpatrick DS, Hackney JA, Wilson MS. Guidi R, et al. Among authors: cheung tk. Cell Rep. 2023 Dec 26;42(12):113515. doi: 10.1016/j.celrep.2023.113515. Epub 2023 Dec 13. Cell Rep. 2023. PMID: 38096048 Free article.
The Staphylococcus aureus ABC-Type Manganese Transporter MntABC Is Critical for Reinitiation of Bacterial Replication Following Exposure to Phagocytic Oxidative Burst.
Coady A, Xu M, Phung Q, Cheung TK, Bakalarski C, Alexander MK, Lehar SM, Kim J, Park S, Tan MW, Nishiyama M. Coady A, et al. Among authors: cheung tk. PLoS One. 2015 Sep 17;10(9):e0138350. doi: 10.1371/journal.pone.0138350. eCollection 2015. PLoS One. 2015. PMID: 26379037 Free PMC article.
101 results