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FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p.
Zhang J, Zhou Y, Huang T, Wu F, Pan Y, Dong Y, Wang Y, Chan AKY, Liu L, Kwan JSH, Cheung AHK, Wong CC, Lo AKF, Cheng ASL, Yu J, Lo KW, Kang W, To KF. Zhang J, et al. Among authors: cheung ahk. Oncogene. 2019 Jan;38(1):33-46. doi: 10.1038/s41388-018-0430-x. Epub 2018 Aug 6. Oncogene. 2019. PMID: 30082912 Free PMC article.
STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker.
Chen B, Chan WN, Mui CW, Liu X, Zhang J, Wang Y, Cheung AHK, Chan AKY, Chan RCK, Leung KT, Dong Y, Pan Y, Ke H, Liang L, Zhou Z, Wong CC, Wu WKK, Cheng ASL, Yu J, Lo KW, To KF, Kang W. Chen B, et al. Among authors: cheung ahk. Mol Cancer. 2021 Nov 12;20(1):147. doi: 10.1186/s12943-021-01451-2. Mol Cancer. 2021. PMID: 34772410 Free PMC article. No abstract available.
MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target.
Wang Y, Chen H, Liu W, Yan H, Zhang Y, Cheung AHK, Zhang J, Chen B, Liang L, Zhou Z, Wong CC, Wu WKK, Chan MWY, Cheng ASL, Ma BBY, Yu J, Lo KW, To KF, Kang W. Wang Y, et al. Among authors: cheung ahk. Theranostics. 2022 Sep 6;12(15):6509-6526. doi: 10.7150/thno.75431. eCollection 2022. Theranostics. 2022. PMID: 36185598 Free PMC article.
Cancer-associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2-IGF1R and Hippo-YAP1 signaling pathways.
Zhang J, Chen B, Li H, Wang Y, Liu X, Wong KY, Chan WN, Chan AK, Cheung AH, Leung KT, Dong Y, Pan Y, Ke H, Liang L, Zhou Z, Xiao J, Wong CC, Wu WK, Cheng AS, Ma BB, Yu J, Lo KW, Kang W; Ka Fai To. Zhang J, et al. J Pathol. 2023 Feb;259(2):205-219. doi: 10.1002/path.6033. Epub 2022 Dec 17. J Pathol. 2023. PMID: 36373776
H. pylori-induced NF-κB-PIEZO1-YAP1-CTGF axis drives gastric cancer progression and cancer-associated fibroblast-mediated tumour microenvironment remodelling.
Chen B, Liu X, Yu P, Xie F, Kwan JSH, Chan WN, Fang C, Zhang J, Cheung AHK, Chow C, Leung GWM, Leung KT, Shi S, Zhang B, Wang S, Xu D, Fu K, Wong CC, Wu WKK, Chan MWY, Tang PMK, Tsang CM, Lo KW, Tse GMK, Yu J, To KF, Kang W. Chen B, et al. Among authors: cheung ahk. Clin Transl Med. 2023 Nov;13(11):e1481. doi: 10.1002/ctm2.1481. Clin Transl Med. 2023. PMID: 37983931 Free PMC article.
57 results