Chern JW - Search Results

1

Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer.

Yu CW, Hung PY, Yang HT, Ho YH, Lai HY, Cheng YS, Chern JW. Yu CW, et al. Among authors: chern jw. J Med Chem. 2019 Jan 24;62(2):857-874. doi: 10.1021/acs.jmedchem.8b01590. Epub 2018 Dec 20. J Med Chem. 2019. PMID: 30525585

2

Benzyl ether-linked glucuronide derivative of 10-hydroxycamptothecin designed for selective camptothecin-based anticancer therapy.

Leu YL, Chen CS, Wu YJ, Chern JW. Leu YL, et al. Among authors: chern jw. J Med Chem. 2008 Mar 27;51(6):1740-6. doi: 10.1021/jm701151c. Epub 2008 Mar 5. J Med Chem. 2008. PMID: 18318465

3

Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase.

Chen CS, Chiou CT, Chen GS, Chen SC, Hu CY, Chi WK, Chu YD, Hwang LH, Chen PJ, Chen DS, Liaw SH, Chern JW. Chen CS, et al. Among authors: chern jw. J Med Chem. 2009 May 14;52(9):2716-23. doi: 10.1021/jm8011905. J Med Chem. 2009. PMID: 19419203

4

Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modification.

You QD, Li ZY, Huang CH, Yang Q, Wang XJ, Guo QL, Chen XG, He XG, Li TK, Chern JW. You QD, et al. Among authors: chern jw. J Med Chem. 2009 Sep 24;52(18):5649-61. doi: 10.1021/jm900469e. J Med Chem. 2009. PMID: 19715319

5

Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.

Chen CS, Tan CM, Huang CH, Chang LC, Wang JP, Cheng FC, Chern JW. Chen CS, et al. Among authors: chern jw. Bioorg Med Chem. 2010 Jan 15;18(2):597-604. doi: 10.1016/j.bmc.2009.12.008. Epub 2009 Dec 6. Bioorg Med Chem. 2010. PMID: 20056549

6

Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors.

Khanwelkar RR, Chen GS, Wang HC, Yu CW, Huang CH, Lee O, Chen CH, Hwang CS, Ko CH, Chou NT, Lin MW, Wang LM, Chen YC, Hseu TH, Chang CN, Hsu HC, Lin HC, Shih YC, Chou SH, Tseng HW, Liu CP, Tu CM, Hu TL, Tsai YJ, Chern JW. Khanwelkar RR, et al. Among authors: chern jw. Bioorg Med Chem. 2010 Jul 1;18(13):4674-86. doi: 10.1016/j.bmc.2010.05.021. Epub 2010 May 12. Bioorg Med Chem. 2010. PMID: 20570526

7

Efficient microwave-assisted Pd-catalyzed hydroxylation of aryl chlorides in the presence of carbonate.

Yu CW, Chen GS, Huang CW, Chern JW. Yu CW, et al. Among authors: chern jw. Org Lett. 2012 Jul 20;14(14):3688-91. doi: 10.1021/ol301523q. Epub 2012 Jul 3. Org Lett. 2012. PMID: 22758780

8

Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease.

Yu CW, Chang PT, Hsin LW, Chern JW. Yu CW, et al. Among authors: chern jw. J Med Chem. 2013 Sep 12;56(17):6775-91. doi: 10.1021/jm400564j. Epub 2013 Aug 16. J Med Chem. 2013. PMID: 23905680

9

Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor.

Wang HC, Jagtap AD, Chang PT, Liu JR, Liu CP, Tseng HW, Chen GS, Chern JW. Wang HC, et al. Among authors: chern jw. Eur J Med Chem. 2014 Sep 12;84:312-34. doi: 10.1016/j.ejmech.2014.07.033. Epub 2014 Jul 10. Eur J Med Chem. 2014. PMID: 25036791

10

Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia.

Jagtap AD, Chang PT, Liu JR, Wang HC, Kondekar NB, Shen LJ, Tseng HW, Chen GS, Chern JW. Jagtap AD, et al. Among authors: chern jw. Eur J Med Chem. 2014 Oct 6;85:268-88. doi: 10.1016/j.ejmech.2014.07.108. Epub 2014 Jul 30. Eur J Med Chem. 2014. PMID: 25089810

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