Cheng M - Search Results

1

Design, synthesis and biological evaluation of carbamate derivatives incorporating multifunctional carrier scaffolds as pseudo-irreversible cholinesterase inhibitors for the treatment of Alzheimer's disease.

Liu Y, Ma C, Li Y, Li M, Cui T, Zhao X, Li Z, Jia H, Wang H, Xiu X, Hu D, Zhang R, Wang N, Liu P, Yang H, Cheng M. Liu Y, et al. Among authors: cheng m. Eur J Med Chem. 2024 Feb 5;265:116071. doi: 10.1016/j.ejmech.2023.116071. Epub 2023 Dec 21. Eur J Med Chem. 2024. PMID: 38157596

2

Design, synthesis, and biological evaluation of aminopyridine derivatives as novel tropomyosin receptor kinase inhibitors.

Lv R, Wang X, Sun Y, Qin Q, Liu N, Wu T, Sun Y, Yin W, Zhao D, Cheng M. Lv R, et al. Among authors: cheng m. Arch Pharm (Weinheim). 2023 Mar;356(3):e2200438. doi: 10.1002/ardp.202200438. Epub 2022 Nov 18. Arch Pharm (Weinheim). 2023. PMID: 36398500

3

Discovery of CZS-241: A Potent, Selective, and Orally Available Polo-Like Kinase 4 Inhibitor for the Treatment of Chronic Myeloid Leukemia.

Sun Y, Xue Y, Liu H, Mu S, Sun P, Sun Y, Wang L, Wang H, Wang J, Wu T, Yin W, Qin Q, Sun Y, Yang H, Zhao D, Cheng M. Sun Y, et al. Among authors: cheng m. J Med Chem. 2023 Feb 23;66(4):2396-2421. doi: 10.1021/acs.jmedchem.2c02124. Epub 2023 Feb 3. J Med Chem. 2023. PMID: 36734825

4

Design, synthesis and biological evaluation of pyrazolo[3,4-b]pyridine derivatives as TRK inhibitors.

Liu N, Wang X, Fu Q, Qin Q, Wu T, Lv R, Zhao D, Cheng M. Liu N, et al. Among authors: cheng m. RSC Med Chem. 2022 Oct 18;14(1):85-102. doi: 10.1039/d2md00334a. eCollection 2023 Jan 25. RSC Med Chem. 2022. PMID: 36760745 Free PMC article.

5

Design, synthesis, and evaluation of N-methyl-propargylamine derivates as isoform-selective monoamine oxidases inhibitors for the treatment of nervous system diseases.

Zhang K, Liu Y, Jia H, Wang H, Deng M, Liu Y, Zhao X, Xiu X, Li Z, Yang H, Cheng M. Zhang K, et al. Among authors: cheng m. Bioorg Chem. 2023 May;134:106441. doi: 10.1016/j.bioorg.2023.106441. Epub 2023 Feb 23. Bioorg Chem. 2023. PMID: 36854233

6

Identification and in silicon binding study of a novel NR2B selective NMDAR antagonist.

Yang C, Wang H, Yang J, Zhang Y, Qin F, He Y, Liu J, Ma C, Cheng M. Yang C, et al. Among authors: cheng m. Bioorg Med Chem Lett. 2023 Apr 1;85:129213. doi: 10.1016/j.bmcl.2023.129213. Epub 2023 Mar 3. Bioorg Med Chem Lett. 2023. PMID: 36870623

7

Design, synthesis and evaluation of OA-tacrine hybrids as cholinesterase inhibitors with low neurotoxicity and hepatotoxicity against Alzheimer's disease.

Yang H, Jia H, Deng M, Zhang K, Liu Y, Liu Y, Cheng M, Xiao W. Yang H, et al. Among authors: cheng m. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2192439. doi: 10.1080/14756366.2023.2192439. J Enzyme Inhib Med Chem. 2023. PMID: 36950955 Free PMC article.

8

Design, synthesis and biological evaluation of novel indolin-2-one derivatives as potent second-generation TRKs inhibitors.

Qin Q, Fu Q, Wang X, Lv R, Lu S, Guo Z, Wu T, Sun Y, Sun Y, Liu N, Zhao D, Cheng M. Qin Q, et al. Among authors: cheng m. Eur J Med Chem. 2023 May 5;253:115291. doi: 10.1016/j.ejmech.2023.115291. Epub 2023 Apr 1. Eur J Med Chem. 2023. PMID: 37030091

9

Discovery of the First Potent, Selective, and In Vivo Efficacious Polo-like Kinase 4 Proteolysis Targeting Chimera Degrader for the Treatment of TRIM37-Amplified Breast Cancer.

Sun Y, Xue Y, Sun P, Mu S, Liu H, Sun Y, Wang L, Wang J, Wu T, Yin W, Qin Q, Sun Y, Liu N, Wang H, Yang H, Zhao D, Cheng M. Sun Y, et al. Among authors: cheng m. J Med Chem. 2023 Jun 22;66(12):8200-8221. doi: 10.1021/acs.jmedchem.3c00505. Epub 2023 Jun 6. J Med Chem. 2023. PMID: 37279162

10

Design, synthesis, and biological evaluation of novel pyrimidin-2-amine derivatives as potent PLK4 inhibitors.

Xue Y, Mu S, Sun P, Sun Y, Liu N, Sun Y, Wang L, Zhao D, Cheng M. Xue Y, et al. Among authors: cheng m. RSC Med Chem. 2023 Jul 20;14(9):1787-1802. doi: 10.1039/d3md00267e. eCollection 2023 Sep 19. RSC Med Chem. 2023. PMID: 37731702

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