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Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target.
Collins CC, Volik SV, Lapuk AV, Wang Y, Gout PW, Wu C, Xue H, Cheng H, Haegert A, Bell RH, Brahmbhatt S, Anderson S, Fazli L, Hurtado-Coll A, Rubin MA, Demichelis F, Beltran H, Hirst M, Marra M, Maher CA, Chinnaiyan AM, Gleave M, Bertino JR, Lubin M, Wang Y. Collins CC, et al. Among authors: cheng h. Mol Cancer Ther. 2012 Mar;11(3):775-83. doi: 10.1158/1535-7163.MCT-11-0826. Epub 2012 Jan 17. Mol Cancer Ther. 2012. PMID: 22252602 Free PMC article.
Next generation patient-derived prostate cancer xenograft models.
Lin D, Xue H, Wang Y, Wu R, Watahiki A, Dong X, Cheng H, Wyatt AW, Collins CC, Gout PW, Wang Y. Lin D, et al. Among authors: cheng h. Asian J Androl. 2014 May-Jun;16(3):407-12. doi: 10.4103/1008-682X.125394. Asian J Androl. 2014. PMID: 24589467 Free PMC article.
Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis.
El-Naggar AM, Somasekharan SP, Wang Y, Cheng H, Negri GL, Pan M, Wang XQ, Delaidelli A, Rafn B, Cran J, Zhang F, Zhang H, Colborne S, Gleave M, Mandinova A, Kedersha N, Hughes CS, Surdez D, Delattre O, Wang Y, Huntsman DG, Morin GB, Sorensen PH. El-Naggar AM, et al. Among authors: cheng h. EMBO Rep. 2019 Dec 5;20(12):e48375. doi: 10.15252/embr.201948375. Epub 2019 Oct 31. EMBO Rep. 2019. PMID: 31668005 Free PMC article.
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