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Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain.
Wang Y, Zhang Z, Yang M, Xiong X, Yan Q, Cao L, Wei P, Zhang Y, Zhang L, Lv K, Chen J, Liu X, Zhao X, Xiao J, Zhang S, Zhu A, Gan M, Zhang J, Cai R, Zhuo J, Zhang Y, Rao H, Qu B, Zhang Y, Chen L, Dai J, Cheng L, Hu Q, Chen Y, Lv H, So RTY, Peiris M, Zhao J, Liu X, Mok CKP, Wang X, Zhao J. Wang Y, et al. Among authors: chen j, chen l, chen y. Cell Rep. 2024 Jan 23;43(1):113653. doi: 10.1016/j.celrep.2023.113653. Epub 2024 Jan 3. Cell Rep. 2024. PMID: 38175758 Free article.
Comparative global B cell receptor repertoire difference induced by SARS-CoV-2 infection or vaccination via single-cell V(D)J sequencing.
He B, Liu S, Xu M, Hu Y, Lv K, Wang Y, Ma Y, Zhai Y, Yue X, Liu L, Lu H, Zhou S, Li P, Mai G, Huang X, Li C, Chen S, Ye S, Zhao P, Yang Y, Li X, Jie Y, Shi M, Yang J, Shu Y, Chen YQ. He B, et al. Among authors: chen yq, chen s. Emerg Microbes Infect. 2022 Dec;11(1):2007-2020. doi: 10.1080/22221751.2022.2105261. Emerg Microbes Infect. 2022. PMID: 35899581 Free PMC article.
Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.
Ma Y, Li P, Hu Y, Qiu T, Wang L, Lu H, Lv K, Xu M, Zhuang J, Liu X, He S, He B, Liu S, Liu L, Wang Y, Yue X, Zhai Y, Luo W, Mai H, Kuang Y, Chen S, Ye F, Zhou N, Zhao W, Chen J, Chen S, Xiong X, Shi M, Pan JA, Chen YQ. Ma Y, et al. Among authors: chen j, chen yq, chen s. PLoS Pathog. 2023 May 17;19(5):e1011123. doi: 10.1371/journal.ppat.1011123. eCollection 2023 May. PLoS Pathog. 2023. PMID: 37196033 Free PMC article.
Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential.
Wang J, Pan YF, Yang LF, Yang WH, Lv K, Luo CM, Wang J, Kuang GP, Wu WC, Gou QY, Xin GY, Li B, Luo HL, Chen S, Shu YL, Guo D, Gao ZH, Liang G, Li J, Chen YQ, Holmes EC, Feng Y, Shi M. Wang J, et al. Among authors: chen yq, chen s. Nat Commun. 2023 Jul 10;14(1):4079. doi: 10.1038/s41467-023-39835-1. Nat Commun. 2023. PMID: 37429936 Free PMC article.
Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1.
Li X, Xu M, Yang J, Zhou L, Liu L, Li M, Wang S, Liu MQ, Huang Z, Zhang Z, Liu S, Hu Y, Lin H, Liu B, Sun Y, Wu Q, Shi ZL, Lan K, Chen Y, Yan H, Chen YQ. Li X, et al. Among authors: chen yq, chen y. Signal Transduct Target Ther. 2024 Apr 27;9(1):114. doi: 10.1038/s41392-024-01822-3. Signal Transduct Target Ther. 2024. PMID: 38678055 Free PMC article.
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