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TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression.
Bi J, Wu Z, Zhang X, Zeng T, Dai W, Qiu N, Xu M, Qiao Y, Ke L, Zhao J, Cao X, Lin Q, Chen XL, Xie L, Ouyang Z, Guo J, Zheng L, Ma C, Guo S, Chen K, Mo W, Fu G, Zhao TJ, Wang HR. Bi J, et al. Among authors: chen k, chen xl. Nat Commun. 2023 Apr 24;14(1):2342. doi: 10.1038/s41467-023-38115-2. Nat Commun. 2023. PMID: 37095176 Free PMC article.
Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt.
Liu C, Ma L, Wang Y, Zhao J, Chen P, Chen X, Wang Y, Hu Y, Liu Y, Jia X, Yang Z, Yin X, Wu J, Wu S, Zheng H, Ma X, Sun X, He Y, Lin L, Fu Y, Liao K, Zhou X, Jiang S, Fu G, Tang J, Han W, Chen XL, Fan W, Hong Y, Han J, Huang X, Li BA, Xiao N, Xiao C, Fu G, Liu WH. Liu C, et al. Among authors: chen xl, chen p, chen x. Sci Adv. 2021 Oct 8;7(41):eabg6262. doi: 10.1126/sciadv.abg6262. Epub 2021 Oct 8. Sci Adv. 2021. PMID: 34623920 Free PMC article.
Themis is indispensable for IL-2 and IL-15 signaling in T cells.
Liu Y, Cong Y, Niu Y, Yuan Y, Tan F, Lai Q, Hu Y, Hou B, Li J, Lin C, Zheng H, Dong J, Tang J, Chen Q, Brzostek J, Zhang X, Chen XL, Wang HR, Gascoigne NRJ, Xu B, Lin SH, Fu G. Liu Y, et al. Among authors: chen xl, chen q. Sci Signal. 2022 Feb 15;15(721):eabi9983. doi: 10.1126/scisignal.abi9983. Epub 2022 Feb 15. Sci Signal. 2022. PMID: 35167340
Themis suppresses the effector function of CD8+ T cells in acute viral infection.
Tang J, Jia X, Li J, Dong J, Wang J, Li W, Zhu Y, Hu Y, Hou B, Lin C, Cong Y, Ren T, Yan C, Yang H, Lai Q, Zheng H, Bao Y, Gautam N, Wang HR, Xu B, Chen XL, Li Q, Gascoigne NRJ, Fu G. Tang J, et al. Among authors: chen xl. Cell Mol Immunol. 2023 May;20(5):512-524. doi: 10.1038/s41423-023-00997-z. Epub 2023 Mar 28. Cell Mol Immunol. 2023. PMID: 36977779 Free PMC article.
2,148 results