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Dysfunction of VIPR2 leads to myopia in humans and mice.
Zhao F, Li Q, Chen W, Zhu H, Zhou D, Reinach PS, Yang Z, He M, Xue A, Wu D, Liu T, Fu Q, Zeng C, Qu J, Zhou X. Zhao F, et al. Among authors: chen w. J Med Genet. 2022 Jan;59(1):88-100. doi: 10.1136/jmedgenet-2020-107220. Epub 2020 Dec 14. J Med Genet. 2022. PMID: 33318135
Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis.
Zhao F, Zhang D, Zhou Q, Zhao F, He M, Yang Z, Su Y, Zhai Y, Yan J, Zhang G, Xue A, Tang J, Han X, Shi Y, Zhu Y, Liu T, Zhuang W, Huang L, Hong Y, Wu D, Li Y, Lu Q, Chen W, Jiao S, Wang Q, Srinivasalu N, Wen Y, Zeng C, Qu J, Zhou X. Zhao F, et al. Among authors: chen w. EBioMedicine. 2020 Jul;57:102878. doi: 10.1016/j.ebiom.2020.102878. Epub 2020 Jul 8. EBioMedicine. 2020. PMID: 32652319 Free PMC article.
PDE4B Proposed as a High Myopia Susceptibility Gene in Chinese Population.
Zhao F, Chen W, Zhou H, Reinach PS, Wang Y, Juo SH, Yang Z, Xue A, Shi Y, Liang CL, Zeng C, Qu J, Zhou X. Zhao F, et al. Among authors: chen w. Front Genet. 2022 Jan 12;12:775797. doi: 10.3389/fgene.2021.775797. eCollection 2021. Front Genet. 2022. PMID: 35116054 Free PMC article.
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.
Tedja MS, Wojciechowski R, Hysi PG, Eriksson N, Furlotte NA, Verhoeven VJM, Iglesias AI, Meester-Smoor MA, Tompson SW, Fan Q, Khawaja AP, Cheng CY, Höhn R, Yamashiro K, Wenocur A, Grazal C, Haller T, Metspalu A, Wedenoja J, Jonas JB, Wang YX, Xie J, Mitchell P, Foster PJ, Klein BEK, Klein R, Paterson AD, Hosseini SM, Shah RL, Williams C, Teo YY, Tham YC, Gupta P, Zhao W, Shi Y, Saw WY, Tai ES, Sim XL, Huffman JE, Polašek O, Hayward C, Bencic G, Rudan I, Wilson JF; CREAM Consortium; 23andMe Research Team; UK Biobank Eye and Vision Consortium; Joshi PK, Tsujikawa A, Matsuda F, Whisenhunt KN, Zeller T, van der Spek PJ, Haak R, Meijers-Heijboer H, van Leeuwen EM, Iyengar SK, Lass JH, Hofman A, Rivadeneira F, Uitterlinden AG, Vingerling JR, Lehtimäki T, Raitakari OT, Biino G, Concas MP, Schwantes-An TH, Igo RP Jr, Cuellar-Partida G, Martin NG, Craig JE, Gharahkhani P, Williams KM, Nag A, Rahi JS, Cumberland PM, Delcourt C, Bellenguez C, Ried JS, Bergen AA, Meitinger T, Gieger C, Wong TY, Hewitt AW, Mackey DA, Simpson CL, Pfeiffer N, Pärssinen O, Baird PN, Vitart V, Amin N, van Duijn CM, Bailey-Wilson JE, Young TL, Saw SM, Stambolian D, MacGregor S, Guggenheim JA, Tung JY, Hammond CJ, K… See abstract for full author list ➔ Tedja MS, et al. Nat Genet. 2018 Jun;50(6):834-848. doi: 10.1038/s41588-018-0127-7. Epub 2018 May 28. Nat Genet. 2018. PMID: 29808027 Free PMC article.
Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium.
Fan Q, Guo X, Tideman JW, Williams KM, Yazar S, Hosseini SM, Howe LD, Pourcain BS, Evans DM, Timpson NJ, McMahon G, Hysi PG, Krapohl E, Wang YX, Jonas JB, Baird PN, Wang JJ, Cheng CY, Teo YY, Wong TY, Ding X, Wojciechowski R, Young TL, Pärssinen O, Oexle K, Pfeiffer N, Bailey-Wilson JE, Paterson AD, Klaver CC, Plomin R, Hammond CJ, Mackey DA, He M, Saw SM, Williams C, Guggenheim JA; CREAM Consortium. Fan Q, et al. Sci Rep. 2016 May 13;6:25853. doi: 10.1038/srep25853. Sci Rep. 2016. PMID: 27174397 Free PMC article.
Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia.
Hong Y, Zhang D, Zhou X, Chen A, Abliz A, Bai J, Wang L, Hu Q, Gong K, Guan X, Liu M, Zheng X, Lai S, Qu H, Zhao F, Hao S, Wu Z, Cai H, Hu S, Ma Y, Zhang J, Ke Y, Wang QF, Chen W, Zeng C. Hong Y, et al. Among authors: chen a, chen w. Genomics Proteomics Bioinformatics. 2022 Feb;20(1):177-191. doi: 10.1016/j.gpb.2021.09.005. Epub 2021 Oct 5. Genomics Proteomics Bioinformatics. 2022. PMID: 34624550 Free PMC article.
How Placenta Promotes the Successful Reproduction in High-Altitude Populations: A Transcriptome Comparison between Adaptation and Acclimatization.
Wu D, Liu Y, Chen W, Shao J, Zhuoma P, Zhao D, Yu Y, Liu T, Yu R, Gan Y, Yuzheng B, Huang Y, Zhang H, Bi X, Tao C, Lai S, Luo Q, Zhang D, Wang H, Zhaxi P, Zhang J, Qiao J, Zeng C. Wu D, et al. Among authors: chen w. Mol Biol Evol. 2022 Jun 2;39(6):msac120. doi: 10.1093/molbev/msac120. Mol Biol Evol. 2022. PMID: 35642306 Free PMC article.
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