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DC isoketal-modified proteins activate T cells and promote hypertension.
Kirabo A, Fontana V, de Faria AP, Loperena R, Galindo CL, Wu J, Bikineyeva AT, Dikalov S, Xiao L, Chen W, Saleh MA, Trott DW, Itani HA, Vinh A, Amarnath V, Amarnath K, Guzik TJ, Bernstein KE, Shen XZ, Shyr Y, Chen SC, Mernaugh RL, Laffer CL, Elijovich F, Davies SS, Moreno H, Madhur MS, Roberts J 2nd, Harrison DG. Kirabo A, et al. Among authors: chen sc, chen w. J Clin Invest. 2014 Oct;124(10):4642-56. doi: 10.1172/JCI74084. Epub 2014 Sep 17. J Clin Invest. 2014. PMID: 25244096 Free PMC article.
Immune activation caused by vascular oxidation promotes fibrosis and hypertension.
Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG. Wu J, et al. Among authors: chen w. J Clin Invest. 2016 Jan;126(1):50-67. doi: 10.1172/JCI80761. Epub 2015 Nov 23. J Clin Invest. 2016. PMID: 26595812 Free PMC article.
Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation.
Saleh MA, McMaster WG, Wu J, Norlander AE, Funt SA, Thabet SR, Kirabo A, Xiao L, Chen W, Itani HA, Michell D, Huan T, Zhang Y, Takaki S, Titze J, Levy D, Harrison DG, Madhur MS. Saleh MA, et al. Among authors: chen w. J Clin Invest. 2015 Mar 2;125(3):1189-202. doi: 10.1172/JCI76327. Epub 2015 Feb 9. J Clin Invest. 2015. PMID: 25664851 Free PMC article.
Immune activation caused by vascular oxidation promotes fibrosis and hypertension.
Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG. Wu J, et al. Among authors: chen w. J Clin Invest. 2016 Apr 1;126(4):1607. doi: 10.1172/JCI87425. Epub 2016 Apr 1. J Clin Invest. 2016. PMID: 27035819 Free PMC article. No abstract available.
Activation of Human T Cells in Hypertension: Studies of Humanized Mice and Hypertensive Humans.
Itani HA, McMaster WG Jr, Saleh MA, Nazarewicz RR, Mikolajczyk TP, Kaszuba AM, Konior A, Prejbisz A, Januszewicz A, Norlander AE, Chen W, Bonami RH, Marshall AF, Poffenberger G, Weyand CM, Madhur MS, Moore DJ, Harrison DG, Guzik TJ. Itani HA, et al. Among authors: chen w. Hypertension. 2016 Jul;68(1):123-32. doi: 10.1161/HYPERTENSIONAHA.116.07237. Epub 2016 May 23. Hypertension. 2016. PMID: 27217403 Free PMC article.
Oligoclonal CD8+ T cells play a critical role in the development of hypertension.
Trott DW, Thabet SR, Kirabo A, Saleh MA, Itani H, Norlander AE, Wu J, Goldstein A, Arendshorst WJ, Madhur MS, Chen W, Li CI, Shyr Y, Harrison DG. Trott DW, et al. Among authors: chen w. Hypertension. 2014 Nov;64(5):1108-15. doi: 10.1161/HYPERTENSIONAHA.114.04147. Epub 2014 Aug 4. Hypertension. 2014. PMID: 25259750 Free PMC article.
Sodium activates human monocytes via the NADPH oxidase and isolevuglandin formation.
Ruggeri Barbaro N, Van Beusecum J, Xiao L, do Carmo L, Pitzer A, Loperena R, Foss JD, Elijovich F, Laffer CL, Montaniel KR, Galindo CL, Chen W, Ao M, Mernaugh RL, Alsouqi A, Ikizler TA, Fogo AB, Moreno H, Zhao S, Davies SS, Harrison DG, Kirabo A. Ruggeri Barbaro N, et al. Among authors: chen w. Cardiovasc Res. 2021 Apr 23;117(5):1358-1371. doi: 10.1093/cvr/cvaa207. Cardiovasc Res. 2021. PMID: 33038226 Free PMC article.
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