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GSK-3484862 targets DNMT1 for degradation in cells.
Chen Q, Liu B, Zeng Y, Hwang JW, Dai N, Corrêa IR Jr, Estecio MR, Zhang X, Santos MA, Chen T, Cheng X. Chen Q, et al. Among authors: chen t. NAR Cancer. 2023 May 17;5(2):zcad022. doi: 10.1093/narcan/zcad022. eCollection 2023 Jun. NAR Cancer. 2023. PMID: 37206360 Free PMC article.
Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Cheng X. Horton JR, et al. Among authors: chen q. J Med Chem. 2018 Dec 13;61(23):10588-10601. doi: 10.1021/acs.jmedchem.8b01219. Epub 2018 Nov 15. J Med Chem. 2018. PMID: 30392349 Free PMC article.
Quinoline-based compounds can inhibit diverse enzymes that act on DNA.
Zhou J, Chen Q, Ren R, Yang J, Liu B, Horton JR, Chang C, Li C, Maksoud L, Yang Y, Rotili D, Zhang X, Blumenthal RM, Chen T, Gao Y, Valente S, Mai A, Cheng X. Zhou J, et al. Among authors: chen q, chen t. bioRxiv [Preprint]. 2024 Apr 3:2024.04.03.587980. doi: 10.1101/2024.04.03.587980. bioRxiv. 2024. PMID: 38617249 Free PMC article. Preprint.
Modulation of DNA damage/DNA repair capacity by XPC polymorphisms.
Zhu Y, Yang H, Chen Q, Lin J, Grossman HB, Dinney CP, Wu X, Gu J. Zhu Y, et al. Among authors: chen q. DNA Repair (Amst). 2008 Feb 1;7(2):141-8. doi: 10.1016/j.dnarep.2007.08.006. Epub 2007 Oct 17. DNA Repair (Amst). 2008. PMID: 17923445 Free PMC article.
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