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Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance.
Azzimato V, Jager J, Chen P, Morgantini C, Levi L, Barreby E, Sulen A, Oses C, Willerbrords J, Xu C, Li X, Shen JX, Akbar N, Haag L, Ellis E, Wålhen K, Näslund E, Thorell A, Choudhury RP, Lauschke VM, Rydén M, Craige SM, Aouadi M. Azzimato V, et al. Among authors: chen p. Sci Transl Med. 2020 Feb 26;12(532):eaaw9709. doi: 10.1126/scitranslmed.aaw9709. Sci Transl Med. 2020. PMID: 32102936
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity.
Azzimato V, Chen P, Barreby E, Morgantini C, Levi L, Vankova A, Jager J, Sulen A, Diotallevi M, Shen JX, Miller A, Ellis E, Rydén M, Näslund E, Thorell A, Lauschke VM, Channon KM, Crabtree MJ, Haschemi A, Craige SM, Mori M, Spallotta F, Aouadi M. Azzimato V, et al. Among authors: chen p. Gastroenterology. 2021 Dec;161(6):1982-1997.e11. doi: 10.1053/j.gastro.2021.08.030. Epub 2021 Aug 21. Gastroenterology. 2021. PMID: 34425095 Free article.
A subset of Kupffer cells regulates metabolism through the expression of CD36.
Blériot C, Barreby E, Dunsmore G, Ballaire R, Chakarov S, Ficht X, De Simone G, Andreata F, Fumagalli V, Guo W, Wan G, Gessain G, Khalilnezhad A, Zhang XM, Ang N, Chen P, Morgantini C, Azzimato V, Kong WT, Liu Z, Pai R, Lum J, Shihui F, Low I, Xu C, Malleret B, Kairi MFM, Balachander A, Cexus O, Larbi A, Lee B, Newell EW, Ng LG, Phoo WW, Sobota RM, Sharma A, Howland SW, Chen J, Bajenoff M, Yvan-Charvet L, Venteclef N, Iannacone M, Aouadi M, Ginhoux F. Blériot C, et al. Among authors: chen j, chen p. Immunity. 2021 Sep 14;54(9):2101-2116.e6. doi: 10.1016/j.immuni.2021.08.006. Epub 2021 Aug 31. Immunity. 2021. PMID: 34469775 Free article.
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce.
Li Q, Hagberg CE, Silva Cascales H, Lang S, Hyvönen MT, Salehzadeh F, Chen P, Alexandersson I, Terezaki E, Harms MJ, Kutschke M, Arifen N, Krämer N, Aouadi M, Knibbe C, Boucher J, Thorell A, Spalding KL. Li Q, et al. Among authors: chen p. Nat Med. 2021 Nov;27(11):1941-1953. doi: 10.1038/s41591-021-01501-8. Epub 2021 Oct 4. Nat Med. 2021. PMID: 34608330
Human resident liver myeloid cells protect against metabolic stress in obesity.
Barreby E, Strunz B, Nock S, Naudet L, Shen JX, Johansson H, Sönnerborg I, Ma J, Urgard E, Pallett LJ, Hu Y, Fardellas A, Azzimato V, Vankova A, Levi L, Morgantini C, Maini MK, Stål P, Rosshart SP, Coquet JM, Nowak G, Näslund E, Lauschke VM, Ellis E, Björkström NK, Chen P, Aouadi M. Barreby E, et al. Among authors: chen p. Nat Metab. 2023 Jul;5(7):1188-1203. doi: 10.1038/s42255-023-00834-7. Epub 2023 Jul 6. Nat Metab. 2023. PMID: 37414931 Free PMC article.
Single-cell RNA counting at allele and isoform resolution using Smart-seq3.
Hagemann-Jensen M, Ziegenhain C, Chen P, Ramsköld D, Hendriks GJ, Larsson AJM, Faridani OR, Sandberg R. Hagemann-Jensen M, et al. Among authors: chen p. Nat Biotechnol. 2020 Jun;38(6):708-714. doi: 10.1038/s41587-020-0497-0. Epub 2020 May 4. Nat Biotechnol. 2020. PMID: 32518404
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes.
He B, Chen P, Zambrano S, Dabaghie D, Hu Y, Möller-Hackbarth K, Unnersjö-Jess D, Korkut GG, Charrin E, Jeansson M, Bintanel-Morcillo M, Witasp A, Wennberg L, Wernerson A, Schermer B, Benzing T, Ernfors P, Betsholtz C, Lal M, Sandberg R, Patrakka J. He B, et al. Among authors: chen p. Nat Commun. 2021 Apr 9;12(1):2141. doi: 10.1038/s41467-021-22331-9. Nat Commun. 2021. PMID: 33837218 Free PMC article.
Cholinergic regulation of vascular endothelial function by human ChAT+ T cells.
Tarnawski L, Shavva VS, Kort EJ, Zhuge Z, Nilsson I, Gallina AL, Martínez-Enguita D, Heller Sahlgren B, Weiland M, Caravaca AS, Schmidt S, Chen P, Abbas K, Wang FH, Ahmed O, Eberhardson M, Färnert A, Weitzberg E, Gustafsson M, Kehr J, Malin SG, Hult H, Carlström M, Jovinge S, Olofsson PS. Tarnawski L, et al. Among authors: chen p. Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2212476120. doi: 10.1073/pnas.2212476120. Epub 2023 Mar 29. Proc Natl Acad Sci U S A. 2023. PMID: 36989306 Free PMC article.
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