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Apicidin-resistant HA22T hepatocellular carcinoma cells strongly activated the Wnt/β-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway enhancing cell metastatic effect.
Hsieh CH, Cheng LH, Hsu HH, Ho TJ, Tu CC, Lin YM, Chen MC, Tsai FJ, Hsieh YL, Huang CY. Hsieh CH, et al. Among authors: chen mc. Biosci Biotechnol Biochem. 2013;77(12):2397-404. doi: 10.1271/bbb.130503. Epub 2013 Dec 7. Biosci Biotechnol Biochem. 2013. PMID: 24317053 Free article.
Estrogen and ERα enhanced β-catenin degradation and suppressed its downstream target genes to block the metastatic function of HA22T hepatocellular carcinoma cells via modulating GSK-3β and β-TrCP expression.
Chen YF, Velmurugan BK, Wang HL, Tu CC, Che RJ, Chen MC, Jen LB, Vishwanadha VP, Hsu HH, Huang CY. Chen YF, et al. Among authors: chen mc. Environ Toxicol. 2017 Feb;32(2):519-529. doi: 10.1002/tox.22256. Epub 2016 Mar 18. Environ Toxicol. 2017. PMID: 26990689
1,453 results