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Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages.
Marcotte H, Cao Y, Zuo F, Simonelli L, Sammartino JC, Pedotti M, Sun R, Cassaniti I, Hagbom M, Piralla A, Yang J, Du L, Percivalle E, Bertoglio F, Schubert M, Abolhassani H, Sherina N, Guerra C, Borte S, Rezaei N, Kumagai-Braesch M, Xue Y, Su C, Yan Q, He P, Grönwall C, Klareskog L, Calzolai L, Cavalli A, Wang Q, Robbiani DF, Hust M, Shi Z, Feng L, Svensson L, Chen L, Bao L, Baldanti F, Xiao J, Qin C, Hammarström L, Yang X, Varani L, Xie XS, Pan-Hammarström Q. Marcotte H, et al. Among authors: chen l. Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2315354120. doi: 10.1073/pnas.2315354120. Epub 2024 Jan 9. Proc Natl Acad Sci U S A. 2024. PMID: 38194459 Free PMC article.
Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection.
Zhang Y, Yan Q, Luo K, He P, Hou R, Zhao X, Wang Q, Yi H, Liang H, Deng Y, Hu F, Li F, Liu X, Feng Y, Li P, Qu L, Chen Z, Pan-Hammarström Q, Feng L, Niu X, Chen L. Zhang Y, et al. Among authors: chen z, chen l. J Virol. 2022 Feb 23;96(4):e0160021. doi: 10.1128/JVI.01600-21. Epub 2021 Dec 8. J Virol. 2022. PMID: 34878902 Free PMC article.
A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape.
Feng B, Chen Z, Sun J, Xu T, Wang Q, Yi H, Niu X, Zhu J, Fan M, Hou R, Shao Y, Huang S, Li C, Hu P, Zheng P, He P, Luo J, Yan Q, Xiong X, Liu J, Zhao J, Chen L. Feng B, et al. Among authors: chen z, chen l. Small Methods. 2022 Jul;6(7):e2200387. doi: 10.1002/smtd.202200387. Epub 2022 May 18. Small Methods. 2022. PMID: 35583124 Free PMC article.
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope.
He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X. He P, et al. Among authors: chen z, chen j, chen l, chen q, chen x. Nat Microbiol. 2022 Oct;7(10):1635-1649. doi: 10.1038/s41564-022-01235-4. Epub 2022 Sep 23. Nat Microbiol. 2022. PMID: 36151403 Free PMC article.
Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants.
Wang Q, Yang C, Yin L, Sun J, Wang W, Li H, Zhang Z, Chen S, Liu B, Liu Z, Shi L, Liu X, Guan S, Wang C, Qu L, Feng Y, Niu X, Feng L, Zhao J, Li P, Chen L, Zhong N. Wang Q, et al. Among authors: chen l, chen s. Signal Transduct Target Ther. 2023 Apr 17;8(1):167. doi: 10.1038/s41392-023-01423-6. Signal Transduct Target Ther. 2023. PMID: 37069171 Free PMC article.
Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2.
Yang PP, Ye XW, Liu MQ, Yang JX, Feng XL, Li YJ, Zhang K, Liang HW, Yi Y, Wang L, Liu YX, Yang XL, Shi ZL, Feng LQ, Chen L, Xue Y, Pan-Hammarström Q, Wang H, Zhao Y. Yang PP, et al. Among authors: chen l. Adv Healthc Mater. 2023 Sep;12(24):e2300673. doi: 10.1002/adhm.202300673. Epub 2023 May 14. Adv Healthc Mater. 2023. PMID: 37139567
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