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Early detection of visual impairment in young children using a smartphone-based deep learning system.
Chen W, Li R, Yu Q, Xu A, Feng Y, Wang R, Zhao L, Lin Z, Yang Y, Lin D, Wu X, Chen J, Liu Z, Wu Y, Dang K, Qiu K, Wang Z, Zhou Z, Liu D, Wu Q, Li M, Xiang Y, Li X, Lin Z, Zeng D, Huang Y, Mo S, Huang X, Sun S, Hu J, Zhao J, Wei M, Hu S, Chen L, Dai B, Yang H, Huang D, Lin X, Liang L, Ding X, Yang Y, Wu P, Zheng F, Stanojcic N, Li JO, Cheung CY, Long E, Chen C, Zhu Y, Yu-Wai-Man P, Wang R, Zheng WS, Ding X, Lin H. Chen W, et al. Among authors: chen j, chen l, chen c. Nat Med. 2023 Feb;29(2):493-503. doi: 10.1038/s41591-022-02180-9. Epub 2023 Jan 26. Nat Med. 2023. PMID: 36702948
Dual base editor catalyzes both cytosine and adenine base conversions in human cells.
Zhang X, Zhu B, Chen L, Xie L, Yu W, Wang Y, Li L, Yin S, Yang L, Hu H, Han H, Li Y, Wang L, Chen G, Ma X, Geng H, Huang W, Pang X, Yang Z, Wu Y, Siwko S, Kurita R, Nakamura Y, Yang L, Liu M, Li D. Zhang X, et al. Among authors: chen l, chen g. Nat Biotechnol. 2020 Jul;38(7):856-860. doi: 10.1038/s41587-020-0527-y. Epub 2020 Jun 1. Nat Biotechnol. 2020. PMID: 32483363
Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing.
Chen L, Zhu B, Ru G, Meng H, Yan Y, Hong M, Zhang D, Luan C, Zhang S, Wu H, Gao H, Bai S, Li C, Ding R, Xue N, Lei Z, Chen Y, Guan Y, Siwko S, Cheng Y, Song G, Wang L, Yi C, Liu M, Li D. Chen L, et al. Among authors: chen y. Nat Biotechnol. 2023 May;41(5):663-672. doi: 10.1038/s41587-022-01532-7. Epub 2022 Nov 10. Nat Biotechnol. 2023. PMID: 36357717
Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD.
Xue N, Liu X, Zhang D, Wu Y, Zhong Y, Wang J, Fan W, Jiang H, Zhu B, Ge X, Gonzalez RVL, Chen L, Zhang S, She P, Zhong Z, Sun J, Chen X, Wang L, Gu Z, Zhu P, Liu M, Li D, Zhong TP, Zhang X. Xue N, et al. Among authors: chen l, chen x. Nat Commun. 2023 Mar 3;14(1):1224. doi: 10.1038/s41467-023-36887-1. Nat Commun. 2023. PMID: 36869044 Free PMC article.
Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage.
Zhang X, Ge L, Jin G, Liu Y, Yu Q, Chen W, Chen L, Dong T, Miyagishima KJ, Shen J, Yang J, Lv G, Xu Y, Yang Q, Ye L, Yi S, Li H, Zhang Q, Chen G, Liu W, Yang Y, Li W, Ou J. Zhang X, et al. Among authors: chen l, chen w, chen g. Nat Commun. 2024 Apr 3;15(1):2859. doi: 10.1038/s41467-024-47095-w. Nat Commun. 2024. PMID: 38570500 Free PMC article.
Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing.
Chen L, Zhu B, Ru G, Meng H, Yan Y, Hong M, Zhang D, Luan C, Zhang S, Wu H, Gao H, Bai S, Li C, Ding R, Xue N, Lei Z, Chen Y, Guan Y, Siwko S, Cheng Y, Song G, Wang L, Yi C, Liu M, Li D. Chen L, et al. Among authors: chen y. Nat Biotechnol. 2024 Apr 24. doi: 10.1038/s41587-024-02252-w. Online ahead of print. Nat Biotechnol. 2024. PMID: 38658731 No abstract available.
Author Correction: Engineering a precise adenine base editor with minimal bystander editing.
Chen L, Zhang S, Xue N, Hong M, Zhang X, Zhang D, Yang J, Bai S, Huang Y, Meng H, Wu H, Luan C, Zhu B, Ru G, Gao H, Zhong L, Liu M, Liu M, Cheng Y, Yi C, Wang L, Zhao Y, Song G, Li D. Chen L, et al. Nat Chem Biol. 2024 Apr 22. doi: 10.1038/s41589-024-01622-4. Online ahead of print. Nat Chem Biol. 2024. PMID: 38649454 No abstract available.
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