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Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial.
Yang W, Zhu D, Gan S, Dong X, Su J, Li W, Jiang H, Zhao W, Yao M, Song W, Lu Y, Zhang X, Li H, Wang G, Qiu W, Yuan G, Ma J, Li W, Li Z, Wang X, Zeng J, Yang Z, Liu J, Liang Y, Lu S, Zhang H, Liu H, Liu P, Fan K, Jiang X, Li Y, Su Q, Ning T, Tan H, An Z, Jiang Z, Liu L, Zhou Z, Zhang Q, Li X, Shan Z, Xue Y, Mao H, Shi L, Ye S, Zhang X, Sun J, Li P, Yang T, Li F, Lin J, Zhang Z, Zhao Y, Li R, Guo X, Yao Q, Lu W, Qu S, Li H, Tan L, Wang W, Yao Y, Chen D, Li Y, Gao J, Hu W, Fei X, Wu T, Dong S, Jin W, Li C, Zhao D, Feng B, Zhao Y, Zhang Y, Li X, Chen L. Yang W, et al. Among authors: chen l, chen d. Nat Med. 2022 May;28(5):974-981. doi: 10.1038/s41591-022-01803-5. Epub 2022 May 12. Nat Med. 2022. PMID: 35551292 Free PMC article. Clinical Trial.
Prevalence of diabetes among men and women in China.
Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, Shan Z, Liu J, Tian H, Ji Q, Zhu D, Ge J, Lin L, Chen L, Guo X, Zhao Z, Li Q, Zhou Z, Shan G, He J; China National Diabetes and Metabolic Disorders Study Group. Yang W, et al. Among authors: chen l. N Engl J Med. 2010 Mar 25;362(12):1090-101. doi: 10.1056/NEJMoa0908292. N Engl J Med. 2010. PMID: 20335585 Free article.
Serum lipids and lipoproteins in Chinese men and women.
Yang W, Xiao J, Yang Z, Ji L, Jia W, Weng J, Lu J, Shan Z, Liu J, Tian H, Ji Q, Zhu D, Ge J, Lin L, Chen L, Guo X, Zhao Z, Li Q, Zhou Z, Shan G, He J; China National Diabetes and Metabolic Disorders Study Investigators. Yang W, et al. Among authors: chen l. Circulation. 2012 May 8;125(18):2212-21. doi: 10.1161/CIRCULATIONAHA.111.065904. Epub 2012 Apr 9. Circulation. 2012. PMID: 22492668
Medical care and payment for diabetes in China: enormous threat and great opportunity.
Yang W, Zhao W, Xiao J, Li R, Zhang P, Kissimova-Skarbek K, Schneider E, Jia W, Ji L, Guo X, Shan Z, Liu J, Tian H, Chen L, Zhou Z, Ji Q, Ge J, Chen G, Brown J. Yang W, et al. Among authors: chen l, chen g. PLoS One. 2012;7(9):e39513. doi: 10.1371/journal.pone.0039513. Epub 2012 Sep 26. PLoS One. 2012. PMID: 23049727 Free PMC article.
Glycemic control among patients in China with type 2 diabetes mellitus receiving oral drugs or injectables.
Ji LN, Lu JM, Guo XH, Yang WY, Weng JP, Jia WP, Zou DJ, Zhou ZG, Yu DM, Liu J, Shan ZY, Yang YZ, Hu RM, Zhu DL, Yang LY, Chen L, Zhao ZG, Li QF, Tian HM, Ji QH, Liu J, Ge JP, Shi LX, Xu YC. Ji LN, et al. Among authors: chen l. BMC Public Health. 2013 Jun 21;13:602. doi: 10.1186/1471-2458-13-602. BMC Public Health. 2013. PMID: 23800082 Free PMC article.
BMI and waist circumference are associated with impaired glucose metabolism and type 2 diabetes in normal weight Chinese adults.
Li S, Xiao J, Ji L, Weng J, Jia W, Lu J, Zhou Z, Guo X, Liu J, Shan Z, Zhu D, Chen L, Zhao Z, Tian H, Ji Q, Ge J, Li Q, Lin L, Yang Z, He J, Yang W; China National Diabetes and Metabolic Disorders Study Investigators. Li S, et al. Among authors: chen l. J Diabetes Complications. 2014 Jul-Aug;28(4):470-6. doi: 10.1016/j.jdiacomp.2014.03.015. Epub 2014 Apr 1. J Diabetes Complications. 2014. PMID: 24809931 Free PMC article.
Dorzagliatin (HMS5552), a novel dual-acting glucokinase activator, improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes: A 28-day treatment study using biomarker-guided patient selection.
Zhu XX, Zhu DL, Li XY, Li YL, Jin XW, Hu TX, Zhao Y, Li YG, Zhao GY, Ren S, Zhang Y, Ding YH, Chen L. Zhu XX, et al. Among authors: chen l. Diabetes Obes Metab. 2018 Sep;20(9):2113-2120. doi: 10.1111/dom.13338. Epub 2018 May 30. Diabetes Obes Metab. 2018. PMID: 29707866 Clinical Trial.
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